糖忧解郁方辅助治疗糖尿病合并抑郁症临床研究  

Clinical Study on Tangyou Jieyu Decoction as Adjunctive Therapy in the Treatment of Diabetes Mellitus with Depression

作　　者：罗震东 张瑜 林东贤 LUO Zhendong;ZHANG Yu;LIN Dongxian(Pharmacy Department,General Hospital of PLA Southern Theater Command,Guangzhou 510010,China;Pharmacy Department,74th Group Army Hospital of the People's Liberation Army,Guangzhou 510318,China)

机构地区：[1]中国人民解放军南部战区总医院药剂科,广东广州510010 [2]中国人民解放军陆军第七十四集团军医院药剂科,广东广州510318

出　　处：《西部中医药》2025年第1期143-146,共4页Western Journal of Traditional Chinese Medicine

摘　　要：目的:观察糖忧解郁方辅助治疗糖尿病合并抑郁症的临床疗效及对血清胶质细胞源性神经营养因子(glial cell line derived neurotrophic factor,GDNF)和P物质(Substance P,SP)的影响。方法:将74例糖尿病合并抑郁症患者随机分为研究组和对照组,每组37例。对照组予常规西药降糖治疗的同时口服谷维素,研究组在对照组治疗基础上服用糖忧解郁方。观察两组患者临床症状积分变化情况,采用抑郁自评量表(Self-rating depression scale,SDS)评估抑郁程度,采用酶联免疫吸附法测定血清GDNF和SP水平,并评估临床疗效及治疗期间安全性。结果:治疗后两组患者各维度症状积分、SDS评分及血清SP表达水平均降低(P<0.05),且研究组降低幅度大于对照组(P<0.05);总有效率研究组[89.2%(33/37)]高于对照组[70.3%(26/37)](P<0.05);治疗后两组患者血清GDNF表达水平均升高(P<0.05),研究组升高幅度大于对照组(P<0.05);两组患者治疗期间均未发生不良反应。结论:糖忧解郁方辅助治疗糖尿病合并抑郁症临床疗效良好,能够有效减轻临床症状,减轻抑郁程度,提高血清GDNF水平,降低SP水平,且无不良反应。Objective:To explore the effects of Tangyou Jieyu prescription as adjunctive therapy in treating diabetes mellitus with depression and its impacts on GDNF and SP.Methods:All 74 patients suffering DM and depression were randomized into the study group and the control group with 37 cases in each group.The control group took oryzanol orally besides the conventional hypoglycaemic therapy of Western medicine,the study group took the prescription on the foundation of the therapy the control group accepted.To observe the changes of clinical symptom scores in the two groups,SDS was used to assess the degrees of depression,ELISA was applied to detect the levels of serum GDNF and SP,to evaluate clinical effects and the safety during the therapeutic period.Results:After the treatment,different dimensional scores of symptoms,SDS scores and the expressions of serum SP were evidently reduced in the two groups(P<0.05),and the decrease of the study group was greater than that of the control group(P<0.05);total effective rate of the study group was[89.2%(33/37)],higher than that[70.3%(26/37)]of the control group(P<0.05);after the treatment,the expressions of serum GDNF were obviously elevated in the two groups(P<0.05),the increase of the study group was more than that of the control group(P<0.05);no adverse reaction occurred in the two groups during therapeutic periods.Conclusion:The prescription as the adjunctive therapy could gain good clinical effects in the treatment of DM and depression,it could effectively relieve clinical symptoms,mitigate depression,lift the levels of serum GDNF and lower the levels of SP without adverse reaction.

关 键 词：糖尿病 抑郁症 糖忧解郁方 胶质细胞源性神经影响因子 P物质 

分 类 号：R255.4[医药卫生—中医内科学]