铁死亡与慢性呼吸系统疾病  

Ferroptosis and Chronic Respiratory Diseases

作　　者：符雯 胡雅梦 陈鑫 刘金保 FU Wen;HU Ya-Meng;CHEN Xin;LIU Jin-Bao(Guangdong Provincial Key Laboratory of Protein Modification and Degradation,Department of Pathophysiology,School of Basic Medicine,Guangzhou Medical University,Guangzhou 511436,China)

机构地区：[1]广州医科大学基础医学院病理生理学教研室,广东省蛋白质修饰与降解重点实验室,广州511436

出　　处：《生理科学进展》2025年第1期4-12,共9页Progress in Physiological Sciences

基　　金：国家自然科学基金(81972399);广东省自然科学基金(2018B030312001);呼吸疾病国家重点实验室开放课题(SKLRD-OP-202313)资助课题。

摘　　要：铁死亡(ferroptosis)是一种整合了代谢紊乱、氧化应激和炎症的非凋亡形式的细胞死亡方式,其特征是铁依赖性脂质过氧化积累。越来越多的文献表明,铁死亡参与了慢性呼吸系统疾病(chronic respiratory diseases)的发病机制。此外,铁死亡相关基因和分子与慢性呼吸系统疾病之间存在一定的联系,这些基因和分子具有作为疾病生物标志物的潜力。本文主要对铁死亡在慢性呼吸系统疾病中作用的研究进展进行总结,进一步讨论了现有的靶向铁死亡治疗慢性呼吸系统疾病的进展,以及将实验研究转化为临床需要克服的主要障碍,为慢性呼吸系统疾病的治疗提供新的启示。Ferroptosis is a non-apoptotic form of cell death that integrates metabolic disorders,oxidative stress,and inflammation,characterized by the accumulation of iron-dependent lipid peroxidation.A growing body of literature suggests that ferroptosis is involved in the pathogenesis of chronic respiratory diseases.In addition,there is a notable association between ferroptosisrelated genes and molecules and chronic respiratory diseases,indicating their potential as disease biomarkers.This article summarizes the research progress on the role of ferroptosis in chronic respiratory diseases,discusses the advances in existing therapies targeting ferroptosis in chronic respiratory diseases,and highlights the main obstacles in translating experimental research into clinical applications,with the aim of providing new insights for the treatment of chronic respiratory diseases.

关 键 词：铁死亡 慢性呼吸系统疾病 炎症 线粒体 脂质代谢 铁蓄积 

分 类 号：R56[医药卫生—呼吸系统]