环状RNA在肺动脉高压中的作用和机制  

Roles and Mechanisms of CircRNA in Pulmonary Hypertension

作　　者：宋新月 朱大岭[1] SONG Xin-Yue;ZHU Da-Ling(Central Laboratory of Harbin Medical University Daqing,Daqing 163711,China)

机构地区：[1]哈尔滨医科大学大庆校区中心实验室,大庆163711

出　　处：《生理科学进展》2025年第1期22-29,共8页Progress in Physiological Sciences

基　　金：国家自然科学基金(31820103007,31971057和31771276)资助课题。

摘　　要：环状RNA(circular RNA, circRNA)作为内源性的非编码RNA在真核生物转录组中普遍存在,调控生物体生命活动的各个方面,如转录调控、表观遗传修饰、信号传导、染色质修饰等,与多种疾病密切相关,发挥着不可或缺的作用。近年来,随着对circRNA研究的不断深入,与肺动脉高压相关的circRNA逐渐被挖掘,使其成为当前肺动脉高压发病机制研究中的新热点。本文重点介绍了circRNA在肺动脉高压领域的研究现状,并探究了其在肺动脉高压中的作用和机制。Circular RNAs(circRNAs),as endogenous non-coding RNAs,are prevalent in the transcriptomes of eukaryotes and regulate various aspects of organisms'life activities,including transcriptional regulation,epigenetic modification,signal transduction,and chromatin modification.These regulatory functions are closely and indispensably linked to a wide range of diseases.In recent years,with circRNA research deepened gradually,circRNAs related to pulmonary hypertension have been increasingly identified,making them a new focus in the current study of pulmonary hypertension pathogenesis.This article presents an overview of the current research status of circRNAs in the field of pulmonary arterial hypertension,elucidating their functional roles and mechanisms underlying the disease.

关 键 词：肺动脉高压 环状RNA 肺血管重构 基因调控 RNA剪切 超级增强子 分子机制 

分 类 号：R332[医药卫生—人体生理学]