呼吸中枢驱动检测及其应用  

Neural Respiratory Drive Test and its Clinical Applications

作　　者：王璐[1] 罗远明[1,2,3] WANG Lu;LUO Yuan-Ming(State Key Laboratory of Respiratory Disease,Guangzhou Medical University,Guangzhou 510163,China;Division of Sleep and Circadian Disorders,Brigham and Women's Hospital and Harvard Medical School,Boston,MA 02115,USA;AISH,Flinders University,Adelaide,SA 5061,Australia)

机构地区：[1]呼吸疾病全国重点实验室,广州医科大学,广州510163 [2]美国哈佛大学医学院布莱根妇女医院睡眠和昼夜节律紊乱科,美国波士顿,MA 02115 [3]弗林德斯大学,澳大利亚阿德莱德,SA 5061

出　　处：《生理科学进展》2025年第1期39-45,共7页Progress in Physiological Sciences

基　　金：国家自然科学基金面上项目(82070090);广州市临床高新技术项目(2023C-GX02);呼吸疾病全国重点实验室临床及流行病学研究专项(J2341X001)资助课题。

摘　　要：膈肌是主要的呼吸肌,其活动可作为呼吸肌功能的代表。膈肌功能可通过其电活动(膈肌肌电)和机械功能如用于反映胸腔压的食道压进行综合评价。与食道压相比,置放准确的多导食道电极所记录的膈肌肌电更能准确反映呼吸中枢驱动。各种呼吸系统疾病包括阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)、慢性阻塞性肺疾病(chronic obstructive pulmonary disease)即慢阻肺病的病理生理改变与呼吸中枢驱动有关。精准记录膈肌肌电,量化呼吸中枢驱动已成为探索疾病发生机理、帮助诊断的重要工具。本文首先介绍食道电极记录膈肌肌电,量化呼吸中枢驱动的方法,并在此基础上总结其对慢性呼吸疾病诊断治疗的价值。The diaphragm is the main respiratory muscle,and its activity can be used to assess respiratory muscle function.Diaphragm function can be evaluated by its electrical activity(diaphragm electromyography,EMGdi)and mechanical functions such as pleural pressure reflected by esophageal pressure.Compared with esophageal pressure,EMGdi recorded by a multipair esophageal electrode catheter could serve as a more reliable biomarker of neural respiratory drive.The pathophysiological changes of various respiratory diseases including obstructive sleep apnea(OSA)and chronic obstructive pulmonary disease are related to neural respiratory drive.Accurately recording EMGdi and quantifying neural respiratory drive has become an important tool for exploring disease pathogenesis and aiding in diagnosis.This article introduces the method for recording EMGdi and quantifying neural respiratory drive using a multipair esophageal electrode catheter,summarizing its value in the diagnosis and treatment of chronic respiratory diseases.

关 键 词：呼吸中枢驱动 食道压 膈肌肌电 阻塞性睡眠呼吸暂停 慢性阻塞性肺疾病 

分 类 号：R332[医药卫生—人体生理学] R563[医药卫生—基础医学]