S1PRs调控的生理功能、疾病发展及靶向药物研究进展  

Recent Advances in S1PR-Mediated Physiological Functions,Disease Progression,and Targeted Therapeutics

作　　者：后叶虎 牛明慧 韩明明 吕鹏强 杨全石 张刚强 陈亮 HOU Ye-Hu;NIU Ming-Hui;HAN Ming-Ming;LV Peng-Qiang;YANG Quan-Shi;ZHANG Gang-Qiang;CHEN Liang(Tianshui Integrated Traditional and Western Medicine Hospital,Tianshui 730000,China;Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]天水市中西医结合医院,天水741000 [2]成都中医药大学,成都611137

出　　处：《生理科学进展》2025年第1期70-76,共7页Progress in Physiological Sciences

基　　金：甘肃天水市科技支撑项目(2022-SHFZKJK-6210)资助课题。

摘　　要：鞘氨醇-1-磷酸(sphingosine-1-phosphate, S1P)是细胞膜鞘脂质的代谢产物,与人体不同部位的G蛋白偶联鞘氨醇-1-磷酸受体(sphingosine-1-phosphate receptors, S1PRs)结合发挥生理功能。S1P-S1PRs信号通路在介导炎症反应、心脏发育、血管生成以及免疫细胞的迁移、增殖和分化等方面发挥重要作用。S1PRs是多种疾病的有效治疗靶点,包括自身免疫性疾病、炎症、心血管疾病甚至癌症等。由于对S1PRs缺乏深入的认识阻碍了临床药物的研发。本文将对S1PRs的研究现状进行综述,将重点关注S1PRs的生理功能、参与疾病发展和代表药物的最新进展,为相关疾病的临床治疗提供新思路。Sphingosine-1-phosphate(S1P),a metabolite of cell membrane sphingolipids,exerts its physiological functions by binding to G protein-coupled sphingosine-1-phosphate receptors(S1PRs)in various tissues of the human body.The S1P-S1PR signaling pathway plays a crucial role in mediating inflammatory responses,cardiac development,angiogenesis,as well as the migration,proliferation,and differentiation of immune cells.S1PRs have emerged as promising therapeutic targets for a variety of diseases,including autoimmune diseases,inflammation,cardiovascular diseases,and even cancer.However,the lack of in-depth understanding of S1PRs has hindered the development of clinical drugs.Therefore,this article reviews the current research status of S1PRs,focusing on S1PR-associated physiological functions,disease progression,and the development of representative drugs,with the aim of providing new insights for the clinical treatment of associated diseases.

关 键 词：S1PRs G蛋白 生理功能 靶向药物 免疫 

分 类 号：R339.2[医药卫生—人体生理学]