肠道菌群代谢产物丙酸咪唑在代谢性疾病和心血管疾病中的作用研究进展  

The Role of Gut Microbial Metabolite Imidazole Propionate in Metabolic and Cardiovascular Diseases

作　　者：吴佳晋 赵志浩 WU Jia-Jin;ZHAO Zhi-Hao(Southeast University School of Medicine,Nanjing 210000,China;Sericultural and Agri-food Research Institute,Guangdong Academy of Agricultural Sciences,Key Laboratory of Functional Foods,Ministry of Agriculture and Rural Affairs,Guangdong Key Laboratory of Agricultural Products Processing,Guangzhou 510610,China)

机构地区：[1]东南大学医学院,南京210000 [2]广东省农业科学院蚕业与农产品加工研究所,农业农村部功能食品重点实验室,广东省农产品加工重点实验室,广州510610

出　　处：《生理科学进展》2025年第1期77-83,共7页Progress in Physiological Sciences

基　　金：国家自然科学基金(32101970);广州市基础与应用基础研究专题项目(2023A04J0829)资助课题。

摘　　要：肠道菌群能够通过代谢产物对宿主多种生理过程产生调控作用,对人体健康至关重要。丙酸咪唑(imidazole propionate)是肠道菌群代谢组氨酸生成的一种代谢产物。近年来,丙酸咪唑由于与2型糖尿病、心血管疾病等慢性疾病的密切关联而受到广泛关注。本文综述了丙酸咪唑的代谢途径、与代谢性疾病和心血管疾病的相关性及其作用机制,以及现有的检测和干预方法,以期为以丙酸咪唑为靶点的慢性疾病防控提供参考。Metabolites produced by the gut microbiota play various physiological regulatory roles through interactions with the host and are closely related to human health.Imidazole propionate,a metabolite derived from histidine by the gut microbiota,has garnered significant attention in recent years due to its close association with chronic diseases such as type 2 diabetes and cardiovascular diseases.This article reviews the metabolic pathways of imidazole propionate,its correlation with metabolic and cardiovascular diseases,its mechanisms of action,and current methods for its detection and associated interventions.The aim is to provide a reference for the prevention and control of chronic diseases targeting imidazole propionate.

关 键 词：肠道菌群 代谢产物 丙酸咪唑 2型糖尿病 心血管疾病 

分 类 号：R589[医药卫生—内分泌] Q939.9[医药卫生—内科学]