直距翠雀花的生物碱成分研究  

Study on the alkaloidal constituents of Delphinium orthocentrum Franchet

作　　者：余榕 林志达 何健民 YU Rong;LIN Zhi-da;HE Jian-min(Technology Center,Gongbei Customs,Zhuhai 519075,China;School of Resource and Environment,Baoshan University,Baoshan 678000,China;Baoshan Key Laboratory of Biodiversity Conservation and Utilization of Gaoligong Mountain,Baoshan 678000,China)

机构地区：[1]拱北海关技术中心,广东珠海519075 [2]保山学院资源环境学院,云南保山678000 [3]保山市高黎贡山生物多样性保护与利用重点实验室,云南保山678000

出　　处：《化学研究与应用》2025年第2期465-469,共5页Chemical Research and Application

基　　金：云南省地方本科高校基础研究联合专项项目(2018FH001-126)资助;怒江下游山地农业生态系统云南省野外科学观测研究站项目(202305AM340031)资助。

摘　　要：采用硅胶柱色谱、凝胶柱色谱和制备型高效液相色谱等分离技术对毛茛科(Ranunculaceae)植物直距翠雀花(Delphinium orthocentrum Franchet)的生物碱类成分进行分离与纯化,并通过核磁共振波谱技术对所分离化合物进行结构鉴定。从直距翠雀花的全草分离和鉴定了9个生物碱类成分,包括7个牛扁碱型C19-二萜生物碱:swinanine A(1)、deacetylswinanine A(2)、tatsiensine(3)、elasine(4)、6-deoxydeltaline(5)、grandifloline C(6)、牛扁碱(7),1个阿朴菲类异喹啉生物碱:木兰碱(8),和1个酰胺化合物2-(acetylamino)benzoic acid,methyl ester(9)。其中化合物3~9首次从该种中鉴定。Separation methods including column chromatography with silica gel and sephadex,and prepared high performance liquid chromatography were applied to isolate and purify the alkaloidal constituents from Delphinium orthocentrum Franchet(Ranunculaceae).Nuclear magnetic resonance spectroscopy was adopted to identify the structures of the isolated compounds.Nine alkaloids were isolated and identified from this plant,including seven C19-lycaconitine type diterpenoid alkaloids swinanine A(1)、deacetylswinanine A(2),tatsiensine(3),elasine(4),6-deoxydeltaline(5),grandifloline C(6),lycoconitine(7),one aporphine-type isoquinoline alkaloid magnoline(8),and one amide alkaloid 2-(acetylamino)benzoic acid,methyl ester(9).Among them,compounds 3~9 were identified in this species for the first time.

关 键 词：直距翠雀花 毛茛科 二萜生物碱 阿朴菲 

分 类 号：O657.7[理学—分析化学]