前蛋白转化酶枯草溶菌素9在心肌缺血再灌注损伤中的分子调控机制及其临床意义  

PCSK9 in Molecular Regulatory Mechanism of Myocardial Ischemia Reperfusion Injury and Its Clinical Significance

作　　者：万正[1] 丁彦春[1] WAN Zheng;DING Yanchun(The Second Hospital of Dalian Medical University,Dalian 116021,Liaoning,China)

机构地区：[1]大连医科大学附属二院,辽宁大连116021

出　　处：《心血管病学进展》2025年第1期25-28,共4页Advances in Cardiovascular Diseases

摘　　要：心肌缺血再灌注损伤(MIRI)是心脏手术和急性心肌梗死治疗中的一个重要问题,而前蛋白转化酶枯草溶菌素9(PCSK9)作为一种调节胆固醇代谢的关键蛋白,其在心脏疾病中的作用日益受到关注。现综述PCSK9在MIRI中的作用及其分子调控机制,探讨PCSK9如何通过影响脂质代谢、炎症反应和氧化应激等途径参与心肌损伤的调控,并分析其在临床治疗中的潜在应用。通过对PCSK9的结构和功能、MIRI的病理生理机制、PCSK9在心肌损伤中的具体作用及其分子调控机制的详细探讨,旨在为未来的研究和临床应用提供理论基础和新思路。特别是PCSK9抑制剂的开发和临床试验显示出其在MIRI治疗中的巨大潜力,未来的研究需进一步阐明PCSK9的具体作用机制,并评估其在临床治疗中的实际效果。Myocardial ischemia reperfusion injury(MIRI)is an important issue in cardiac surgery and the treatment of acute myocardial infarction,and proprotein convertase subtilisin/kexin type 9(PCSK9),as a key protein regulating cholesterol metabolism,is increasingly being studied for its role in heart disease.This article reviews the role and molecular regulatory mechanisms of PCSK9 in MIRI,discusses how PCSK9 is involved in the regulation of myocardial injury through pathways such as lipid metabolism,inflammatory response,and oxidative stress,and analyzes its potential applications in clinical treatment.By exploring the structure and function of PCSK9,the pathophysiological mechanisms of MIRI,the specific role of PCSK9 in myocardial injury,and its molecular regulatory mechanisms in detail,this article aims to provide a theoretical basis and new ideas for future research and clinical applications.In particular,the development and clinical trials of PCSK9 inhibitors have shown great potential in the treatment of MIRI,and further research is needed to elucidate the specific mechanisms of action of PCSK9 and evaluate its actual effectiveness in clinical treatment.

关 键 词：前蛋白转化酶枯草溶菌素9 心肌缺血再灌注损伤 分子调控机制 信号通路 临床意义 

分 类 号：R54[医药卫生—心血管疾病]