脂滴与细胞器之间的相互作用在心血管疾病中的研究进展  

The Interaction Between Lipid Droplets and Organelles in Cardiovascular Disease

作　　者：蒲思颖 胡朗 郭艳杰 李妍 PU Siying;HU Lang;GUO Yanjie;LI Yan(Xi’an Medical College,Xi’an 710021,Shaanxi,China;Department of Cardiology,The Second Affiliated Hospital of Air Force Medical University,Xi’an 710038,Shaanxi,China;Department of Cardiology,Xi’an International Medical Center Hospital,Xi’an 710100,Shaanxi,China)

机构地区：[1]西安医学院,陕西西安710021 [2]空军军医大学第二附属医院心血管内科,陕西西安710038 [3]西安国际医学中心医院心内科,陕西西安710100

出　　处：《心血管病学进展》2025年第1期37-41,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(81770369,82070385);陕西省自然科学基金(2022SF-317)。

摘　　要：细胞器不仅具有各自特定的功能,还能通过相互作用来共同完成重要的生理功能。脂滴是一种特殊而动态的细胞器,对细胞和器官的健康起着重要作用。近年来,人们对脂滴在代谢性疾病的发生和发展中扮演的角色越来越关注。脂滴的形成、代谢以及与其他细胞器的相互作用共同驱动了细胞内脂质的稳态调控。现综述最新的研究进展,总结脂滴与胞内细胞器之间的相互作用,并探讨它们如何共同影响心血管疾病的发生和进展。Organelles not only have specific functions but also cooperate through interactions to fulfill important physiological functions.Lipid droplets,as unique and dynamic organelles,play a vital role in cellular and organ health.In recent years,there has been increasing attention on the role of lipid droplets in the occurrence and progression of metabolic disease.The formation,metabolism,and interaction of lipid droplets with other organelles collectively drive the homeostatic regulation of cellular lipids.This review aims to summarize the latest research progress,explore the interplay between lipid droplets and intracellular organelles,and discuss how they jointly impact the occurrence and progression of cardiovascular disease.

关 键 词：脂滴 细胞器互作 心血管疾病 内质网 线粒体 

分 类 号：R54[医药卫生—心血管疾病]