通窍活血汤加减联合盐酸多奈哌齐治疗瘀血阻窍型血管性痴呆的效果及对认知功能的影响  

Effect of modified Tongqiao Huoxue decoction combined with donepezil hydrochloride in the treatment of vascular dementia of blood stasis obstructing orifice type and its influence on cognitive function

作　　者：顾玉宝 曹晖 甘佳乐 GU Yubao;CAO Hui;GAN Jiale(Ningxia Hui Autonomous Region Chinese Medicine Hospital and Research Institute,Yinchuan 750021,China)

机构地区：[1]宁夏回族自治区中医医院暨中医研究院,宁夏银川750021

出　　处：《临床医学研究与实践》2025年第5期89-92,共4页Clinical Research and Practice

基　　金：宁夏回族自治区中医药管理局建设京宁中医药合作第四批重点专科项目;宁夏自然科学基金项目(No.2022AAC03415);宁夏医科大学科学研究基金资助项目(No.XM2021101)。

摘　　要：目的探讨通窍活血汤加减联合盐酸多奈哌齐治疗瘀血阻窍型血管性痴呆(VD)的效果及对认知功能的影响。方法选取2022年1月至2023年12月在宁夏回族自治区中医医院暨中医研究院住院的70例瘀血阻窍型VD患者,按随机数字表法将其分为对照组和观察组,各35例。两组均给予常规治疗,对照组给予盐酸多奈哌齐治疗,观察组在对照组基础上加用通窍活血汤加减治疗。比较两组的治疗效果。结果治疗后,两组的表情呆滞、反应迟缓、少言寡语评分均降低,且观察组低于对照组(P<0.05)。治疗后,两组的简易精神状态量表(MMSE)、蒙特利尔认知评测量表(MoCA)评分均升高,且观察组高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的白细胞介素-6(IL-6)水平均降低,脑源性神经营养因子(BDNF)、神经生长因子(NGF)水平均升高,且观察组优于对照组,差异具有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论通窍活血汤加减联合盐酸多奈哌齐治疗瘀血阻窍型VD的临床效果显著,能有效改善临床症状,提高认知功能,减轻炎症反应,调节神经因子水平,且未增加不良反应。Objective To explore the effect of modified Tongqiao Huoxue decoction combined with donepezil hydrochloride in the treatment of vascular dementia(VD)of blood stasis obstructing orifice type and its influence on cognitive function.Methods From January 2022 to December 2023,70 patients with VD of blood stasis obstructing orifice type who were hospitalized in Ningxia Hui Autonomous Region Chinese Medicine Hospital and Research Institute were selected and divided into control group and observation group according to the random number table method,with 35 cases in each group.Both groups were given routine treatment,the control group was treated with donepezil hydrochloride,and the observation group was treated with modified Tongqiao Huoxue decoction on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the scores of dull expression,slow response and few words in the two groups decreased,and those in the observation group were lower than the control group(P<0.05).After treatment,the scores of the Mini-Mental State Examination(MMSE)and Montreal Cognitive Assessment(MoCA)in the two groups increased,those in the observation group were higher than the control group,and the differences were statistically significant(P<0.05).After treatment,the level of interleukin-6(IL-6)in the two groups decreased,while the levels of brain-derived neurotrophic factor(BDNF)and nerve growth factor(NGF)increased,those in the observation group were better than the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The modified Tongqiao Huoxue decoction combined with donepezil hydrochloride in the treatment of VD of blood stasis obstructing orifice type has a significant clinical effect.It can effectively improve clinical symptoms,enhance cognitive function,reduce inflammatory response,and regulate the level of nerve factors,and does not increa

关 键 词：通窍活血汤 盐酸多奈哌齐 血管性痴呆 瘀血阻窍型 

分 类 号：R277.7[医药卫生—中医学]