智能响应型水凝胶在关节软骨损伤修复中的应用与进展  

Application and progress of intelligent responsive hydrogels in articular cartilage injury repair

作　　者：徐青雨 张保健 李红日 刘成日 毕书浩 杨智翔 刘彦群 XU Qingyu;ZHANG Baojian;LI Hongri;LIU Chengri;BI Shuhao;YANG Zhixiang;LIU Yanqun(Orthopedic Diagnosis and Treatment Center,Yanbian University Hospital(Yanbian Hospital),Yanji Jilin,133000,P.R.China)

机构地区：[1]延边大学附属医院(延边医院)骨科诊疗中心,吉林延吉133000

出　　处：《中国修复重建外科杂志》2025年第2期250-256,共7页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：吉林省科技发展计划项目(20220402082GH)。

摘　　要：目的综述不同智能响应型水凝胶在关节软骨损伤修复中的研究进展。方法广泛查阅国内外相关文献,对不同类型智能响应型水凝胶修复关节软骨损伤的动物实验和临床研究进行归纳和总结。结果关节软骨损伤后自我修复能力有限,而不同类型智能响应型水凝胶,如温度敏感型、光敏型、酶反应型、pH敏感型等,可通过相应刺激使水凝胶发生相变,以达到最佳功能状态,使损伤软骨得到填充,同时刺激软骨细胞增殖、分化,快速修复损伤部位。随着软骨组织工程材料的研究,智能响应型水凝胶为软骨损伤修复提供了新思路。结论智能响应型水凝胶是一种可变、可控、高效、稳定的高分子聚合物,具有与关节软骨相似的组织结构和功能特性,是关节软骨损伤修复的重要生物材料之一。但目前仍缺乏统一的治疗标准和简单、高效的制备技术。Objective To review clinical application and research progress of different types of intelligent responsive hydrogels in repairing articular cartilage injury.Methods The animal experiments and clinical studies of different types of intelligent responsive hydrogels for repairing articular cartilage injury were summarized by reviewing relevant literature at home and abroad.Results The intrinsic regenerative capacity of articular cartilage following injury is limited.Intelligent responsive hydrogels,including those that are temperature-sensitive,light-sensitive,enzymeresponsive,pH-sensitive,and other stimuli-responsive hydrogels,can undergo phase transitions in response to specific stimuli,thereby achieving optimal functionality.These hydrogels can fill the injured cartilage area,promote the proliferation and differentiation of chondrocytes,and expedite the repair of the damaged site.With advancements in cartilage tissue engineering materials research,intelligent responsive hydrogels offer a novel approach and promising potential for the treatment of cartilage injuries.Conclusion Intelligent responsive hydrogel is a kind of flexible,controllable,efficient,and stable polymer,which has similar structure and functional properties to articular cartilage,and has become one of the important biomaterials for cartilage repair.However,there is still a lack of unified treatment standards and simple and efficient preparation technology.

关 键 词：智能响应型水凝胶 响应原理 软骨损伤 修复 

分 类 号：R68[医药卫生—骨科学]