Exploration of evolutionary mechanisms shaping KZFP and retrotransposon interactions  

塑造KZFP与逆转录转座子互作的进化机制的探索研究

作　　者：Qian Wu Junqin Xu Jiaxin Zeng Yixuan Wang Peng Yang 吴骞;徐君琴;曾家鑫;王译萱;杨鹏

机构地区：[1]Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation,Clinical Research Center for Anesthesiology and Perioperative Medicine,Translational Research Institute of Brain and Brain-Like Intelligence,Shanghai Fourth People’s Hospital,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China [2]Institute for Regenerative Medicine,State Key Laboratory of Cardiology and Medical Innovation Center,Shanghai East Hospital,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China

出　　处：《Science Bulletin》2025年第3期328-332,共5页科学通报(英文版)

基　　金：supported by the Ministry of Science and Technology of China(2021YFA1102000);the National Natural Science Foundation of China(32070652,32271355,32022024 and 32270850);the Shuguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission(20SG21 and 22SG20).

摘　　要：Retrotransposon expansion has profoundly reshaped genomes[1],[2].As crucial defense mechanisms that counteract retrotransposons in humans,members of the Krüppel-associated box(KRAB)zinc finger(ZF)protein(KZFP)family have undergone significant changes in both their numbers and binding capabilities[3].

关 键 词：SHAPED EXPANSION mechanisms 

分 类 号：O62[理学—有机化学]