Human cardiac organoid model reveals antibacterial triclocarban promotes myocardial hypertrophy by interfering with endothelial cell metabolism  

人类心脏类器官模型显示抗菌剂三氯卡班通过干扰内皮细胞代谢促进心肌肥厚

作　　者：Nana Yang Jiahong Chen Yujie Zhu Wenxin Shan Zheng Cao Yiwen Fu Huanhuan Cao Yanyan Li Yukun Xiang Shusi Ding Huiqing Wang Yaobo Zhao Liang Ji Rui Zhan Yufei Wu Zhaomeng Wang Manyuan Dong Lemin Zheng 杨娜娜;陈嘉洪;朱玉洁;单文心;曹政;付艺文;曹缓缓;李艳艳;项宇坤;丁曙思;王惠青;赵耀波;季亮;战锐;武玉飞;王兆盟;董满园;郑乐民

机构地区：[1]School of Bioscience and Technology,Weifang Key Laboratory of Animal Model Research on Cardiovascular and Cerebrovascular Diseases,Shandong Second Medical University,Weifang 261053,China [2]The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine,School of Basic Medical Sciences,State Key Laboratory of Vascular Homeostasis and Remodeling,NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Beijing Key Laboratory of Cardiovascular Receptors Research,Health Science Center,Peking University,Beijing 100191,China [3]University of Chinese Academy of Sciences,Beijing 100049,China [4]Beijing Tiantan Hospital,China National Clinical Research Center for Neurological Diseases,Advanced Innovation Center for Human Brain Protection,Beijing Institute of Brain Disorders,The Capital Medical University,Beijing 100050,China [5]Research Center for Cardiopulmonary Rehabilitation,University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital),School of Health and Life Sciences,University of Health and Rehabilitation Sciences,Qingdao 266071,China

出　　处：《Science Bulletin》2025年第3期342-346,共5页科学通报(英文版)

基　　金：supported by the National High Technology Research and Development Program of China(2020YFA0803700 and 2023YFA1800904);the Natural Science Foundation of Beijing,China(L232031 and J230039);the Postdoctoral Fellowship Program of CPSF(GZC20240068);the China Postdoctoral Science Foundation(2021M690252 and 2021TQ0019);the National Natural Science Foundation of China(82371363)。

摘　　要：Environmental pollution is an important but often overlooked risk factor for cardiovascular diseases such as heart failure.Triclocarban(3,4,4′-trichlorocarbanilide,TCC)is a broad-spectrum antibacterial agent commonly used in personal care products such as antibacterial soaps,detergents,toothpaste,and cosmetics[1].Unfortunately,due to its widespread use,TCC has become one of the top ten most common water pollutants globally,and it is present in the atmosphere,soil,and aquatic sediments[2].

关 键 词：metabolism CARDIOVASCULAR diseases 

分 类 号：R54[医药卫生—心血管疾病] X503.1[医药卫生—内科学]