Temporal-specific single-cell atlas of human type A aortic dissection reveals immune cell dynamics and therapeutic targets  

人A型主动脉夹层单细胞图谱揭示疾病亚型特异性免疫景观与治疗靶点

作　　者：Wenting Zhao Juan Chen Yi Xia Zhixi Wei Sitong Wan Huiyuan Guo Yanling Hao Wenjian Jiang Hongjia Zhang Fazheng Ren Peng An Yongting Luo Junjie Luo 赵文婷;陈娟;夏祎;魏芷茜;宛思彤;郭慧媛;郝彦玲;姜文剑;张宏家;任发政;安鹏;罗永挺;罗俊杰

机构地区：[1]Department of Nutrition and Health,China Agricultural University,Beijing 100193,China [2]Department of Cardiovascular Surgery,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China

出　　处：《Science Bulletin》2025年第2期167-171,共5页科学通报(英文版)

基　　金：supported by the State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,Chinese Academy of Medical Sciences(2024GZkf-05);the Beijing Municipal Natural Science Foundation(7222111);the National Natural Science Foundation of China(31970717,82170429,and 32371229);the Pinduoduo-China Agricultural University Research Fund(PC2023B01014)。

摘　　要：Stanford type A aortic dissection(STAAD/AD)is a degenerative aortic remodeling disease with an extremely high mortality rate and poor prognosis[1,2].Dissections can be classified into acute(<14 d),subacute(15–90 d),and chronic(>90 d)stages depending on the time interval between the onset of initial symptoms and presentations[3].Patients who survive the acute phase progress to subacute and ultimately chronic stages[4,5].

关 键 词：DISSECTION ACUTE AORTIC 

分 类 号：R54[医药卫生—心血管疾病]