Yolk–shell Au@carbon nanospheres with photothermal and electronplunder sterilization for infected wound healing  

具有光热和电子掠夺杀菌功能的蛋黄-蛋壳结构金@多孔碳纳米球用于感染伤口愈合

作　　者：Jin Chai Changzhen Qu Kunpeng Li Jiaheng Liang Qian Zhou Rong Zhuang Shuo Wang Fei Xu Qingyan Jia Peng Li 柴进;曲昌镇;李琨鹏;梁嘉恒;周倩;庄容;王烁;徐飞;贾庆岩;李鹏(Frontiers Science Center for Flexible Electronics(FSCFE),Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&Engineering(IBME),Northwestern Polytechnical University,Xi’an 710072,China;State Key Laboratory of Solidification Processing,Center for Nano Energy Materials,School of Materials Science and Engineering,Northwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene(NPU),Xi’an 710072,China)

机构地区：[1]Frontiers Science Center for Flexible Electronics(FSCFE),Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&Engineering(IBME),Northwestern Polytechnical University,Xi’an 710072,China [2]State Key Laboratory of Solidification Processing,Center for Nano Energy Materials,School of Materials Science and Engineering,Northwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene(NPU),Xi’an 710072,China

出　　处：《Science China Materials》2025年第2期597-609,共13页中国科学(材料科学)(英文版)

基　　金：financially supported by the National Natural Science Foundation of China (52273302 and 52473265);the Shaanxi Provincial Science Fund for Distinguished Young Scholars (2023-JC-JQ-32);the Ningbo Natural Science Foundation (2021J050);the Fundamental Research Funds for the Central Universities, China。

摘　　要：Highly pathogenic-resistant bacteria infectionsseriously hinder the wound healing process and induce a catastrophic threat to human health. Incorporating multipleantibacterial strategies into nanostructured materials has beenverified to possess paramount promise for amelioratingtherapeutic efficiency against resistant bacteria. Herein, amultifunctional yolk–shell nanocomposite (Au@HCN) comprised of an aurum (Au) core and hollow carbon nanosphere(HCN) shell was prepared via one-step copolymerization andcarbonization. The electron plunder by Au@HCN on thebacterial membrane leads to bacterial membrane depolarization and enhanced reactive oxygen species (ROS) metabolism,resulting in remarkable efficacy against drug-resistant bacteriaunder dark conditions. Moreover, the synergetic photothermaltherapy (PTT) displayed significant antibacterial properties(~98%) when exposed to near-infrared (NIR) irradiation invitro. Meanwhile, efficient eradication of drug-resistant bacteria in the infected wound in vivo was observed under NIRexposure, thereby promoting wound healing through theprominent antibacterial properties of Au@HCN. The yolk–shell Au@HCN possesses tremendous potential for combatingmultidrug resistance with high efficiency.高度致病性耐药菌感染严重阻碍了伤口愈合过程,并对人类健康构成巨大威胁.将多种抗菌策略整合到纳米结构材料中已被证明在提高耐药菌治疗效率方面具有极大潜力.在此,我们通过一步共聚和碳化的方法制备了一种多功能蛋黄-蛋壳结构纳米复合材料(Au@HCN),该材料由金(Au)核心和空心碳纳米球(HCN)壳组成.Au@HCN对细菌膜的电子掠夺导致细菌膜去极化和活性氧(ROS)代谢增强,在黑暗条件下对耐药菌表现出显著的抗菌效果.此外,在体外近红外(NIR)照射下,协同光热治疗(PTT)显示出显著的抗菌特性(~98%).同时,在体内感染伤口中,NIR照射下有效消除了耐药菌,从而通过Au@HCN显著的抗菌特性促进了伤口愈合.蛋黄壳Au@HCN在高效对抗多重耐药性方面具有巨大潜力.

关 键 词：wound infection drug-resistant bacteria photothermal therapy electron transfer NANOCARBON 

分 类 号：R318.08[医药卫生—生物医学工程] TB383.1[医药卫生—基础医学]