特发性肺纤维化合并EB病毒血症患者的临床特征和预后分析  

Clinical characteristics and prognosis⁃analysis study of idiopathic pulmonary fibrosis patients with Epstein⁃Barr viraemia

作　　者：刘寅[1,2] 姜涵毅 曹敏[1] 赵婷婷[1] 肖永龙[1] 苏欣[2] Liu Yin;Jiang Hanyi;Cao Min;Zhao Tingting;Xiao Yonglong;Su Xin(Department of Respiratory and Critical Care Medicine,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院呼吸与危重症医学科,南京210008 [2]南京大学医学院附属金陵医院呼吸与危重症医学科

出　　处：《临床内科杂志》2025年第1期35-38,共4页Journal of Clinical Internal Medicine

基　　金：国家自然科学基金资助项目(82270019)。

摘　　要：目的总结分析特发性肺纤维化(IPF)合并EB病毒(EBV)血症患者的临床特点和预后。方法回顾性纳入2017年1月~2019年12月南京大学医学院附属鼓楼医院呼吸与危重症医学科住院的68例IPF患者,根据外周血EBV DNA结果将其分为EBV血症组(31例)和阴性组(37例),比较两组患者的一般临床资料、实验室检查指标、影像学及肺功能检查结果和预后。采用Kaplan⁃Meier法分析患者生存率并进行组间比较。结果EBV血症组年龄、WBC计数、单核细胞计数、女性及磨玻璃影患者比例均高于阴性组,NK细胞绝对计数及其占淋巴细胞百分比、氧合指数均低于阴性组(P<0.05)。Kaplan⁃Meier生存分析结果显示,EBV血症组患者30 d生存率低于阴性组(P<0.05)。结论EBV血症在IPF患者中常见,外周血EBV DNA阳性的IPF患者病情更严重、预后更差。Objective To summarize and analyze the clinical features and prognosis of patients with idiopathic pulmonary fibrosis(IPF)complicated with Epstein Barr virus(EBV).Methods A total of 68 patients with IPF who were hospitalized in the department of Respiratory and Critical Care Medicine,Drum Tower Hospital Affiliated to the School of Medicine of Nanjing University from January 2017 to December 2019 were retrospectively included.According to the results of EBV DNA,they were divided into two groups:EB viremia group(31 cases)and negative group(37 cases).General clinical data,laboratory examination indexes,imaging and pulmonary function examination results and prognosis of the two groups were compared.The survival rate was calculated by Kaplan⁃Meier method and compared between groups.Results Age,WBC count,monocyte count,proportion of female and ground glass shadow patients in EB viremia group were higher than those in negative group,and the absolute NK cell count,its percentage in lymphocyte and oxygenation index were lower than those in negative group(P<0.05).Kaplan⁃Meier survival analysis showed that the 30 d survival rate in EB viremia group was lower than that in negative group(P<0.05).Conclusion EB viremia is common in IPF patients,and IPF patients with positive EBV DNA in peripheral blood have more severe disease and worse prognosis.

关 键 词：EB病毒 特发性肺纤维化 单核细胞计数 自然杀伤细胞 

分 类 号：R563.13[医药卫生—呼吸系统]