血清铁蛋白水平在隐匿性乙型肝炎病毒感染女性患者中的临床意义及其与肝功能指标的相关性  

Clinical significance of serum ferritin level in female patients with occult hepatitis Bvirus infection and its correlation with liver function indicators

作　　者：陶弋婧 饶丽华 杨松 TAO Yijing;RAO Lihua;YANG Song(Department of Medical Laboratory,Jiangxi Hospital of Integrated Chinese and Western Medicine,Nanchang 330003,CHINA)

机构地区：[1]江西省中西医结合医院医学检验科,江西南昌330003

出　　处：《江苏医药》2025年第1期33-36,共4页Jiangsu Medical Journal

基　　金：江西省卫健委科技计划项目(202311235)。

摘　　要：目的分析血清铁蛋白(SF)在隐匿性乙型肝炎病毒感染(OBI)女性患者中的临床意义及其与肝功能指标的相关性。方法根据乙型肝炎病毒血清标志物检测结果,270例女性受检者分为A组(OBI患者,145例)、B组(慢性乙型肝炎患者,64例)和C组(健康人群,61例)。比较三组SF水平和肝功能指标。A组又分为A1组(SF水平异常,72例)和A2组(SF水平正常,73例),比较两组的肝功能指标。分析A组SF水平与肝功能指标的相关性。结果与C组比较,A组SF和ALP水平升高(P<0.05和P<0.01),B组SF、ALT水平升高(P<0.01)。与B组比较,A组SF水平升高,而血清DBil水平降低(P<0.05)。与A2组比较,A1组血清ALT、AST、γ-谷氨酰转肽酶(GGT)、ALP、TBil水平均升高,而血清白蛋白水平降低(P<0.05或P<0.01)。A组SF水平与血清ALT、AST、GGT、ALP、TBil及球蛋白水平呈正相关(P<0.05或P<0.01)。结论SF水平在OBI女性患者中异常升高,且与部分肝功能指标呈正相关,有助于评估肝脏炎性损伤。Objective To analyze the clinical significance of serum ferritin(SF)level in female patients with occult hepatitis B virus infection(OBI)and its correlation with the liver function indicators.Methods According to test results of hepatitis B virus serum markers,270o female subjects were divided into groups of A(OBI,145 cases),B(chronic hepatitis B,64 cases)and C(healthy controls,61 cases).SF level and liver function indicators of three groups were compared.Group A was subdivided into groups of A1(with abnormal SF level,72 cases)and A2(with normal SF level,73 cases).The liver function indicators were compared between groups of Al and A2.The correlation between SF level and liver function indicators in group A was analyzed.Results Compared with group C,levels of SF and ALP were increased in group A(P<0.05 and P<0.01),levels of SF and ALT were increased in group B(P<0.01).Compared with group B,SF level was increased,while serum DBil level was decreased in group A(P<0.05).Compared with group A2,serum levels of ALT,AST,Y-glutamyl transpeptidase(GGT),ALP and TBil were increased,while serum albumin level was decreased in group A1(P<0.05 or P<0.01).SF level was positively correlated with serum levels of ALT,AST,GGT,ALP,TBil and globulin in group A(P<0.05 or P<0.01).Conclusion SF level is abnormally elevated in female patients with OBI,and it is positively correlated with some liver function indicators,which is helpful to evaluate liver inflammatory injury.

关 键 词：铁蛋白 隐匿性乙型肝炎病毒感染 肝功能 

分 类 号：R512[医药卫生—内科学]