血清铁蛋白联合孕周对胎膜早破并发宫内感染的预测价值  

Predictive value of serum ferritin combined with gestational week for premature rupture of membranes complicated by intrauterine infection

作　　者：但跃 邹恋 陈佳 徐艳 殷溶[1] DAN Yue;ZOU Lian;CHEN Jia;XU Yan;YIN Rong(Department of Obstetrics and Gynecology,Chongqing Emergency Medical Center/Chongqing Fourth People′s Hospital,Chongqing 400014,China)

机构地区：[1]重庆市急救医疗中心/重庆市第四人民医院妇产科,重庆400014

出　　处：《检验医学与临床》2025年第4期457-460,465,共5页Laboratory Medicine and Clinic

基　　金：重庆市科卫联合医学科研项目(2023QNXM019)。

摘　　要：目的评估血清铁蛋白、孕周预测胎膜早破产妇宫内感染的价值。方法回顾性分析2019年4月至2021年4月于该中心分娩的137例胎膜早破产妇临床资料,记录产妇确诊胎膜早破时血清铁蛋白水平、孕周,分娩后评估宫内感染程度并分组(未感染组、感染组,其中感染组又分为轻度感染组、中度感染组和重度感染组3个亚组)。比较感染组与未感染组,轻度感染组、中度感染组及重度感染组的孕周、血清铁蛋白水平。分析血清铁蛋白、孕周与胎膜早破产妇宫内感染的相关性。采用受试者工作特征(ROC)曲线分析血清铁蛋白、孕周对胎膜早破产妇宫内感染的预测价值。结果感染组孕周小于未感染组,血清铁蛋白水平高于未感染组,差异均有统计学意义(P<0.05)。重度感染组孕周最小,中度感染组次之,轻度感染组最大,3组比较,差异均有统计学意义(P<0.05);重度感染组血清铁蛋白水平最高,中度感染组次之,轻度感染组最低,3组比较,差异均有统计学意义(P<0.05)。点二列相关分析结果显示,血清铁蛋白、孕周与胎膜早破产妇宫内感染具有相关性(r=0.401、-0.310,P<0.05);Spearman相关分析结果显示,血清铁蛋白、孕周与胎膜早破产妇宫内感染程度也存在相关性(rs=0.828、-0.878,P<0.05)。ROC曲线分析结果显示,孕周、血清铁蛋白单独及联合预测胎膜早破产妇宫内感染的曲线下面积分别为0.720、0.818、0.839。结论孕周、血清铁蛋白对胎膜早破产妇宫内感染有一定的预测价值,且血清铁蛋白水平越高、孕周越小越容易发生宫内感染。Objective To evaluate the predictive value of serum ferritin and gestational week for intrauterine infection in women with premature rupture of membranes.Methods A retrospective analysis was conducted on the clinical data of 137 women who delivered at this center from April 2019 to April 2021 with premature rupture of membranes.The serum ferritin level and gestational week were recorded at the time of diagnosis of premature rupture of membranes.After delivery,the degree of intrauterine infection was assessed,and the patients were grouped into the non-infection group and the infection group.The infection group was further divided into the mild infection group,the moderate infection group and the severe infection group.The gestational week and serum ferritin level were compared between the infection group and the non-infection group,as well as among the mild,moderate and severe infection subgroups.The correlation between serum ferritin level,gestational week and intrauterine infection in pregnant women with premature rupture of membranes was analyzed.Receiver operating characteristic(ROC)curve analysis was used to evaluate the predictive value of serum ferritin level and gestational week for intrauterine infection in women with premature rupture of membranes.Results The gestational week in the infection group was lower than that in the non-infection group,while the serum ferritin level was higher in the infection group than that in the non-infection group,and the differences were statistically significant(P<0.05).The gestational week was the smallest in the severe infection group,followed by the moderate infection group and the largest in the mild infection group.There were statistically significant differences among the three groups(P<0.05).The serum ferritin level was highest in the severe infection group,followed by the moderate infection group,and lowest in the mild infection group.The differences among the three groups were statistically significant(P<0.05).The results of the point biserial correlation analysi

关 键 词：胎膜早破 宫内感染 铁蛋白 孕周 预测 

分 类 号：R714.2[医药卫生—妇产科学] R446.1[医药卫生—临床医学]