重组人干扰素α-2b阴道片联合聚焦超声治疗高危型HPV感染的疗效及对T细胞亚群、炎症因子的影响  

Efficacy of recombinant human interferonα-2b vaginal tablets combined with focused ultrasound in the treatment of high-risk human papillomavirus infection and its effects on T cell subsets and inflammatory factors

作　　者：孙琮 刘静 刘琦 乔丽 SUN Cong;LIU Jing;LIU Qi;QIAO Li(Department of and Gynecology,First Hospital of Zibo,Zibo,Shandong 255200,China)

机构地区：[1]山东省淄博市第一医院妇科,山东淄博255200

出　　处：《检验医学与临床》2025年第4期470-474,共5页Laboratory Medicine and Clinic

基　　金：山东省淄博市医药卫生科研项目(20230501061)。

摘　　要：目的探讨重组人干扰素α-2b阴道片联合聚焦超声治疗高危型人乳头瘤病毒(HPV)感染的临床效果,并观察其对HPV转阴率、白带清洁度、T细胞亚群、炎症因子的影响。方法选择2022年6月至2023年6月该院收治的高危型HPV感染患者100例作为研究对象,采用随机数字表法将患者分为对照组(重组人干扰素α-2b阴道片治疗)和观察组(重组人干扰素α-2b阴道片+聚焦超声治疗),各50例。比较2组治疗后HPV转阴率、白带清洁度,以及2组治疗前后T细胞亚群(CD4^(+)T细胞比例、CD8^(+)T细胞比例、CD4^(+)/CD8^(+)T细胞比值)、炎症因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、降钙素原(PCT)]水平。比较2组总有效率和不良反应总发生率。结果治疗后,与对照组比较,观察组的HPV转阴率、白带清洁度正常率更高(P<0.05)。治疗后,与对照组比较,观察组的CD4^(+)T细胞比例、CD4^(+)/CD8^(+)T细胞比值更高,CD8^(+)T细胞比例,以及CRP、IL-6、PCT水平更低,差异均有统计学意义(P<0.05)。与对照组相比,观察组的总有效率更高(P<0.05),不良反应总发生率更低(P<0.05)。结论重组人干扰素α-2b阴道片联合聚焦超声能够升高HPV转阴率和白带清洁度正常率,改善患者的免疫功能和炎症反应,提高治疗疗效,降低患者的不良反应发生率。Objective To investigate the clinical efficacy of recombinant human interferonα-2b vaginal tablets combined with focused ultrasound in the treatment of high-risk human papillomavirus(HPV)infection,and to observe its effects on the HPV clearance rate,vaginal discharge cleanliness,T cell subsets and inflammatory factors.Methods A total of 100 patients with high-risk HPV infection treated in the hospital from June 2022 to June 2023 were selected as study subjects.Patients were divided into the control group(treated with recombinant human interferonα-2b vaginal tablets)and the observation group(treated with recombinant human interferonα-2b vaginal tablets+focused ultrasound)using the random number table method,with 50 cases in each group.The HPV clearance rate and vaginal discharge cleanliness were compared between the two groups after treatment,as well as T lymphocyte subsets(proportion of CD4^(+)T cells,proportion of CD8^(+)T cells,CD4^(+)/CD8^(+)T cell ratio)and levels of inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6)procalcitonin(PCT)]before and after treatment in both groups.The overall effectiveness rate and incidence of adverse reactions were compared between the two groups.Results After treatment,the HPV clearance rate and the normal rate of vaginal discharge cleanliness in the observation group were significantly higher than those in the control group(P<0.05).Additionally,the proportions of CD4^(+)T cells and CD4^(+)/CD8^(+)T cell ratio were higher in the observation group,while the proportions of CD8^(+)T cells,as well as the levels of CRP,IL-6 and PCT were lower in the observation group,compared with those in the control group,with all differences being statistically significant(P<0.05).Compared with the control group,the overall response rate was higher in the observation group(P<0.05),and the overall incidence of adverse reactions was lower in the observation group(P<0.05).Conclusion Recombinant human interferonα-2b vaginal tablets combined with focused ultrasound can increase the H

关 键 词：重组人干扰素α-2b阴道片 聚焦超声 高危型人乳头瘤病毒 CD4^(+)T细胞 C反应蛋白 白细胞介素-6 降钙素原 

分 类 号：R711.74[医药卫生—妇产科学] R446.11[医药卫生—临床医学]