HLA-C、HLA-E、HLA-G在子痫前期孕妇胎盘中表达的研究进展  

Research progress on the expression of HLA-C,HLA-E and HLA-G in the placenta of pregnant women with preeclampsia

作　　者：张悦 王鸿运 关亚平(综述) 徐爱群(审校) ZHANG Yue;WANG Hongyun;GUAN Yaping;XU Aiqun(Second Clinical Medical College,Binzhou Medical University,Yantai,Shandong 264000,China;Department of Obstetrics,Yantai Affiliated Hospital of Binzhou Medical University,Yantai,Shandong 264100,China)

机构地区：[1]滨州医学院第二临床医学院,山东烟台264000 [2]滨州医学院烟台附属医院产科,山东烟台264100

出　　处：《检验医学与临床》2025年第4期568-572,共5页Laboratory Medicine and Clinic

摘　　要：子痫前期(PE)是妊娠期高血压疾病的一种类型,也是一种常见的妊娠并发症,威胁孕妇和围生儿生命安全。PE发病机制复杂多样,目前普遍认为是由于胎盘滋养层细胞的侵入不足导致子宫螺旋动脉重铸异常,进而导致胎盘血供不足、缺氧,从而引发多种胎盘因子释放进入母体,极大地激活了母体系统的炎症反应。妊娠期人类白细胞抗原(HLA)-C、HLA-E、HLA-G在绒毛外细胞的滋养层中表达,作用于免疫细胞,对母体免疫起到关键性的调节作用,当免疫失衡时,可引起PE的发生。该文旨在通过对正常妊娠及PE孕妇中HLA-C、HLA-E、HLA-G的免疫调节进行综述,进一步了解HLA分子在正常妊娠及PE孕妇中的不同作用,探讨PE患者的免疫失衡机制,为PE的早期诊断和干预提供更多参考,以期改善母婴结局。但该文有关PE具体作用机制方面未具体阐述,需要未来更多研究者们进一步深入研究。Preeclampsia(PE)is a type of hypertensive disorder in pregnancy and a common pregnancy complication that poses a threat to the life and health of both the mother and the fetus.The pathogenesis of PE is complex and multifactorial,and it is generally believed to result from insufficient invasion of trophoblasts,leading to abnormal remodeling of the uterine spiral arteries.This causes inadequate placental blood supply and hypoxia,which in turn triggers the release of various placental factors into the maternal circulation,significantly activating the maternal systemic inflammatory response.Human leukocyte antigen(HLA)-C,HLA-E and HLA-G are expressed in the trophoblast layer of the villous cytotrophoblasts during pregnancy,where they interact with immune cells and play a crucial role in regulating the maternal immune system.When immune imbalance occurs,it can lead to the development of PE.This article aims to review the immunoregulatory roles of HLA-C,HLA-E and HLA-G in normal pregnancy and PE women,further elucidating their distinct functions in both conditions.The article also explores the mechanisms of immune imbalance in PE women,providing insights for the early diagnosis and intervention of PE,with the goal of improving maternal and fetal outcomes.However,the specific mechanisms of PE remain insufficiently addressed in this review and will require further in-depth research by future studies to fully understand.

关 键 词：子痫前期 免疫失衡 人类白细胞抗原-C 人类白细胞抗原-E 人类白细胞抗原-G 

分 类 号：R714.7[医药卫生—妇产科学] R446.11[医药卫生—临床医学]