sST2在儿童变应性鼻炎特异性免疫治疗中的评估作用  

Evaluation of sST2 in specific immunotherapy for allergic rhinitis in children

作　　者：王孝玮 罗焕君 王静[3] 孔海波 周琴[3] WANG Xiaowei;LUO Huanjun;WANG Jing;KONG Haibo;ZHOU Qin(Tongxiang First People’s Hospital,Tongxiang 314500,China;Xingyang Maternal and Child Health Hospital,Xingyang 450100,China;Zhejiang Provincial People’s Hospital,Hangzhou 310000,China)

机构地区：[1]桐乡市第一人民医院,浙江桐乡314500 [2]荥阳市妇幼保健院,河南荥阳450100 [3]浙江省人民医院,浙江杭州310000

出　　处：《浙江实用医学》2024年第6期464-467,485,共5页Zhejiang Practical Medicine

摘　　要：目的探讨变应性鼻炎(AR)患儿血清可溶性生长刺激表达基因2蛋白(sST2)表达情况,分析血清sST2变化与特异性免疫疗效指标的相关性。方法收集2022年9月~2024年1月浙江省人民医院行SCIT治疗AR患儿47例。治疗前和治疗1年后用ELISA试剂盒检测血清sST2水平、血清总IgE、血清嗜酸性粒细胞百分比和计数、血清尘螨组分IgG4,并对患儿进行FeNO、问卷评分,分析血清sST2水平与上述指标的相关性。结果SCIT治疗1年后,患儿血清IgE、Der p1 IgG4和Der p2 IgG4含量升高,嗜酸性粒细胞百分比、FeNO、RQLQ、TNSS,TMS、VAS症状量表及VAS生活量表、血清sST2呈下降趋势;差异均有统计学意义(P<0.05或P<0.01)。SCIT治疗1年后,血清sST2变化与TMS评分具有相关性(P<0.05),且血清sST2变化与Der p2 IgG4具有相关性(P<0.01)。结论SCIT治疗有助于改善AR患儿症状及生活质量,且sST2在治疗过程中逐渐下降,且与患儿用药评分改善与血清尘螨组分Der p2 IgG4水平变化呈显著相关性。血清sST2有望成为预测AR患儿SCIT疗效评估的潜在指标,为临床诊疗提供参考。Objective To investigate the expression of soluble growth stimulating gene 2 protein(sST2)in serum of children with allergic rhinitis(AR),and to analyze the correlation between changes in serum sST2 and specific immune efficacy indicators.Method 47 children with AR who underwent SCIT treatment at Zhejiang Provincial People’s Hospital from September 2022 to January 2024 were collected.Serum sST2 levels,serum total IgE,serum eosinophil percentage and count,serum dust mite component IgG4 were detected using ELISA kits before and after 1 year of treatment.FeNO and questionnaire scores were performed on the affected children to analyze the correlation between serum sST2 levels and the above indicators.Result After one year of SCIT treatment,the levels of serum IgE,Der p1 IgG4,and Der p2 IgG4 in the children increased,while the percentage of eosinophils,FeNO,RQLQ,TNSS,TMS,VAS symptom scale,VAS life scale,and serum sST2 showed a decreasing trend;The differences were statistically significant(P<0.05 or P<0.01).After 1 year of SCIT treatment,there was a correlation between serum sST2 changes and TMS scores(P<0.05),and serum sST2 changes were correlated with Der p2 IgG4(P<0.01).Conclusion SCIT treatment can help improve the symptoms and quality of life of children with AR,and sST2 gradually decreases during the treatment process,and is significantly correlated with the improvement of medication scores and changes in serum dust mite component Der p2 IgG4 levels in children.Serum sST2 is expected to become a potential indicator for predicting the efficacy evaluation of SCIT in children with AR,providing reference for clinical diagnosis and treatment.

关 键 词：变应性鼻炎 儿童 特异性免疫治疗 sST2 

分 类 号：R54[医药卫生—心血管疾病]