江苏省成年居民骨密度异常患病情况及其影响因素分析  

Prevalence of abnormal bone mineral density and its influencing factors among adult residents in Jiangsu province:a cross-sectional survey

作　　者：王伟壕 何慧婧[1,2] 胡耀达 陈兴明 许锬[4] 涂吉[1,2] 李昂 林彬彬 刘启航 陆治名 席天舒 黄海波 许达 陈智立 王子超 单广良 WANG Weihao;HE Huijing;HU Yaoda;CHEN Xingming;XU Tan;TU Ji;LI Ang;LIN Binbin;LIU Qihang;LU Zhiming;XI Tianshu;HUANG Haibo;XU Da;CHEN Zhili;WANG Zichao;SHAN Guangliang(Department of Epidemiology and Statistics,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences&School of Basic Medicine,Peking Union Medical College,Beijing 100005,China;State Key Laboratory of Common Mechanism Research for Major Diseases,Beijing 100005,China;Department of Otorhinolaryngology Head and Neck Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Epidemiology,School of Public Health,Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases,Suzhou Medical College of Soochow University,Suzhou 215123,China)

机构地区：[1]中国医学科学院基础医学研究所/北京协和医学院基础学院流行病与卫生统计学系,北京100005 [2]重大疾病共性机制研究全国重点实验室,北京100005 [3]中国医学科学院北京协和医学院北京协和医院耳鼻咽喉头颈外科,北京100730 [4]苏州大学苏州医学院公共卫生学院流行病学教研室江苏省老年病预防与转化重点实验室,苏州215123

出　　处：《中国公共卫生》2024年第11期1289-1294,共6页Chinese Journal of Public Health

基　　金：中国医学科学院医学与健康科技创新工程“国民重要生理指标参考值范围研究”(2021–I2M–1–023);重大疾病共性机制研究全国重点实验室2023重点室自主研究课题任务计划(2060204)。

摘　　要：目的了解江苏省成年居民骨密度异常患病情况及其影响因素,为制定骨质疏松症的预防控制措施提供参考依据。方法于2023年10—11月采取多阶段整群随机抽样方法在江苏省抽取6000名≥20岁成年居民进行问卷调查、体格检查、实验室检测和骨密度测量,并应用多因素非条件logistic回归模型分析该地区成年居民骨密度异常患病的主要影响因素。结果江苏省最终纳入分析的5786名成年居民中,骨密度异常、骨量减少和骨质疏松症患病数分别为1280、1148和132例,患病率分别为22.12%、19.84%和2.28%;2265名男性成年居民中,骨密度异常、骨量减少和骨质疏松症患病数分别为624、560和64例,患病率分别为27.55%、24.72%和2.83%;3521名女性成年居民中,骨密度异常、骨量减少和骨质疏松症患病数分别为656、588和68例,患病率分别为18.63%、16.70%和1.93%;江苏省不同性别成年居民比较,男性居民骨密度异常、骨量减少和骨质疏松症的患病率均高于女性居民,差异均有统计学意义(χ^(2)=63.625、55.792和4.944,均P<0.05)。多因素非条件logistic回归分析结果显示,年龄≥60岁和既往发生脆性骨折是江苏省男性成年居民骨密度异常患病的危险因素,大专及以上文化程度是江苏省男性成年居民骨密度异常患病的保护因素;年龄≥60岁、高血压和已绝经是江苏省女性成年居民骨密度异常患病的危险因素,中学文化程度和中度体力劳动是江苏省女性成年居民骨密度异常患病的保护因素。结论江苏省成年居民骨密度异常患病率较低,男性居民骨密度异常患病率高于女性居民,年龄和文化程度是该地区男性和女性成年居民骨密度异常患病的共同影响因素。Objective To investigate the prevalence of abnormal bone mineral density(BMD)and its influencing factors among adults in Jiangsu province,to provide a reference for the development of prevention and control measures for osteoporosis.Methods Using stratified multistage cluster random sampling,we recruited 6000 adult permanent residents(≥20 years old and living locally for at least 5 years)without disability or serious illness and,for women,not pregnant or breastfeeding,in urban and rural areas of Jiangsu province.Participants underwent a face-to-face interview with a self-designed questionnaire,physical examination,laboratory tests,and measurement of calcaneal BMD using the Pegasus ultrasound bone densitometer between October and November 2023.A multifactorial unconditional logistic regression model was used to analyze the main factors influencing abnormal BMD in the participants.Results A total of 5786 adults were included in the final analysis.The numbers of participants with abnormal BMD,osteopenia,and osteoporosis were 1280,1148,and 132,with prevalence rates of 22.12%,19.84%,and 2.28%,respectively.Among 2265 male participants,the numbers with abnormal BMD,osteopenia,and osteoporosis were 624,560,and 64,with prevalence rates of 27.55%,24.72%,and 2.83%,respectively;among 3521 female participants,the numbers with abnormal BMD,osteopenia,and osteoporosis were 656,588,and 68,with prevalence rates of 18.63%,16.70%,and 1.93%,respectively.The prevalence rates of abnormal BMD,osteopenia,and osteoporosis were all significantly higher in male participants than in female participants(χ^(2)=63.625,55.792,and 4.944,all P<0.05).Multivariate unconditional logistic regression analysis showed that age≥60 years and history of fragility fracture were risk factors for abnormal BMD in male adults,whereas education of college degree or higher was a protective factor.Age≥60 years,hypertension,and menopause were risk factors for abnormal BMD in female adults,whereas high school education and moderate physical work were protecti

关 键 词：骨密度异常 患病情况 影响因素 成年居民 

分 类 号：R580[医药卫生—内分泌]