骨质疏松中衰老相关分泌表型调控机制的研究进展  

Research Progress on the Regulation Mechanism of Senescence-associated Secretory Phenotype in Osteoporosis

作　　者：杨超富 谭国庆[2] 徐展望[2] YANG Chaofu;TAN Guoqing;XU Zhanwang(Shandong University of Traditional Chinese Medicine,Jinan 250039,China;Spinal Department,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250013,China)

机构地区：[1]山东中医药大学,山东省济南市250039 [2]山东中医药大学附属医院脊柱脊髓科,山东省济南市250013

出　　处：《中国全科医学》2024年第29期3685-3695,共11页Chinese General Practice

基　　金：国家自然科学基金面上项目(82174410);山东省自然科学基金资助项目(ZR2020KH011);山东省自然科学基金面上项目(ZR2020MH362);全国名老中医专家传承工作室建设项目(国中医药人教函[202275号])。

摘　　要：衰老相关分泌表型(SASP)是细胞衰老的重要特征,在调控疾病微环境中具有重要作用。目前,对于SASP干预骨代谢、诱导骨流失的作用机制了解有限,因此,本文探讨了在骨质疏松模型中SASP的调控机制,并归纳总结了其调控特点:SASP在衰老骨细胞中充分表达,以自分泌/旁分泌的方式将衰老效应传递到间充质干细胞,从而干预其成骨分化;SASP激活免疫细胞,并促进其衰老,从而诱导炎性组织微环境的形成,加重骨流失;线粒体稳态失调、病理性血糖升高、肥胖诱导的脂肪蓄积均会促进SASP的表达,从而扰乱微环境稳态,将衰老效应传递到骨组织。所以,有必要深入了解SASP在骨质疏松中的作用,为后续开发抗SASP疗法治疗骨质疏松提供借鉴。Senescence-associated secretory phenotype(SASP)is an important feature of cellular senescence and plays an important role in regulating the disease microenvironment.At present,the role of SASP in intervening bone metabolism and inducing bone loss is very limited.Therefore,this paper discusses the regulatory mechanism of SASP in osteoporosis models and summarizes its regulatory characteristics:SASP is fully expressed in senescent bone cells and transmits aging effects to mesenchymal stem cells in an autocrine/paracrine manner,thereby interfering with osteogenic differentiation.SASP activates immune cells and promotes their aging,thus inducing the formation of inflammatory tissue microenvironment and aggravating bone loss.Mitochondrial homeostasis,pathologic hyperglycemia,and obesity-induced fat accumulation all promote SASP expression,thus disrupting microenvironmental homeostasis and transmitting aging effects to bone tissue.To sum up,understanding the role of SASP in osteoporosis lays a solid foundation for us to develop anti-SASP therapy for osteoporosis in the future.

关 键 词：骨质疏松 衰老相关分泌表型 细胞衰老 代谢紊乱 免疫调节 

分 类 号：R681[医药卫生—骨科学]