莫西沙星治疗老年肺炎的效果与安全性分析  

Analysis of Efficacy and Safety Moxifloxacin in the Treatment of Elderly Pneumonia

作　　者：杜婷婷 李艳琴 DU Tingting;LI Yanqin(Department of Pharmacy,Fuxian People’s Hospital,Yan’an 727500,Shaanxi Province,China;Department of Pharmacy,Fuxian Hospital of Traditional Chinese Medicine,Yan’an 727500,Shaanxi Province,China)

机构地区：[1]富县人民医院药剂科,陕西延安727500 [2]富县中医医院药剂科,陕西延安727500

出　　处：《中国实用乡村医生杂志》2025年第1期5-8,12,共5页Chinese Practical Journal of Rural Doctor

摘　　要：目的探讨莫西沙星治疗老年肺炎的效果与安全性。方法选取2021年2月—2024年3月富县人民医院收治的106例老年肺炎患者,根据随机数字表法随机分为对照组和观察组各53例。经相关实验室病原菌等检查后,对照组予以阿奇霉素治疗,观察组予以莫西沙星治疗。比较分析两组临床症状消失时间、住院时间、治疗后肺功能、治疗期间的不良反应发生情况,以及治疗前后的呼吸功能和炎性因子水平。结果观察组患者咳嗽、咳痰、肺部啰音、呼吸不畅消失时间及住院时间均短于对照组,差异具有统计学意义(P<0.05)。治疗后两组呼吸功能指标中呼吸频次、浅快呼吸指数、氧合指数、通气情况水平均较治疗前得到改善,且治疗后观察组上述指标水平均优于对照组,差异具有统计学意义(P<0.05)。治疗后观察组患者肺功能各指标水平均高于对照组,差异具有统计学意义(P<0.05)。治疗后两组患者炎性因子各指标水平均低于治疗前,且治疗后观察组上述指标水平均低于对照组,差异具有统计学意义(P<0.05)。观察组不良反应总发生率为7.55%,低于对照组的11.32%,但差异无统计学意义(P>0.05)。结论莫西沙星治疗老年肺炎具有较好的效果,能够有效减轻患者临床症状,降低炎性因子水平,且具有较好的安全性,值得推广使用。Objective To explore the efficacy and safety of moxifloxacin in the treatment of elderly pneumonia.Methods A total of 106 elderly patients with pneumonia admitted to Fuxian People’s Hospital from February 2021 to March 2024 were randomly divided into a control group and an observation group,with 53 cases in each group,using a random number table method.After relevant laboratory pathogen tests,the control group was treated with azithromycin,while the observation group was treated with moxifloxacin.Compare and analyze the disappearance time of clinical symptoms,length of hospital stay,post-treatment lung function,incidence of adverse reactions during treatment,as well as respiratory function and inflammatory factor levels before and after treatment between two groups.Results The disappearance time of cough,sputum,pulmonary rales,respiratory distress,and hospitalization time in the observation group were significantly shorter than those in the control group(P<0.05).After treatment,the respiratory function indicators of the two groups improved in terms of respiratory frequency,shallow and rapid breathing index,oxygenation index,and ventilation level compared to before treatment.Moreover,the observation group showed significantly better levels of these indicators than the control group after treatment(P<0.05).After treatment,the levels of various indicators of lung function in the observation group were significantly higher than those in the control group(P<0.05).After treatment,the levels of inflammatory factors in both groups of patients were lower than before treatment,and the levels of the above indicators in the observation group were significantly lower than those in the control group after treatment(P<0.05).The total incidence of adverse reactions in the observation group was 7.55%,which was lower than the 11.32%in the control group,but the difference was not statistically significant(P>0.05).Conclusion Moxifloxacin has high antibacterial activity and broad-spectrum antibacterial effects in the treatment of e

关 键 词：肺炎 老年 药物治疗 莫西沙星 效果 安全性 

分 类 号：R56[医药卫生—呼吸系统]