尿微量白蛋白与尿肌酐联合诊断糖尿病肾病的价值  

Value Analysis of Combined Test of Urinary Microalbumin and Urinary Creatinine in Diagnosis of Diabetes Nephropathy

作　　者：林小花 林苏媚 徐文泉 LIN Xiaohua;LIN Sumei;XU Wenquan(Laboratory Department,Guangzhou Zengcheng District Xintang Town Central Health Center,Guangzhou,Guangdong 511340;Medical Technology Department,Guangzhou Zengcheng District Zengjiang Street Community Health Service Center,Guangzhou,Guangdong 511316;Laboratory Department,Guangzhou Zengcheng District Traditional Chinese Medicine Hospital,Guangzhou,Guangdong 511300)

机构地区：[1]广州市增城区新塘镇中心卫生院检验科,广东广州511340 [2]广州市增城区增江街社区卫生服务中心医技科,广东广州511316 [3]广州市增城区中医医院检验科,广东广州511300

出　　处：《智慧健康》2024年第36期39-42,共4页Smart Healthcare

摘　　要：目的分析通过检验尿微量白蛋白及尿肌酐预测糖尿病肾病情况的价值。方法选取本院在2023年6月1日—2024年5月31日接收的疑似糖尿病肾病的患者50例为研究对象。采集研究对象的中段尿液样本10 mL,将其送至实验室进行尿微量白蛋白与尿肌酐水平的测定,并对50例疑似患者进行肾穿刺活检,以肾穿刺活检作为诊断的金标准,分析尿微量白蛋白、尿肌酐及其比值的诊断糖尿病肾病的效能。结果经肾穿刺活检诊断,在50例疑似患者中,存在糖尿病肾病34例、单纯糖尿病16例。单纯糖尿病组尿微量白蛋白、尿肌酐水平及尿微量白蛋白/尿肌酐比值均低于糖尿病肾病组(P<0.05);尿微量白蛋白与尿肌酐比值诊断糖尿病肾病的准确度、特异度、灵敏度均高于各指标单一检测水平,差异有统计学意义(P<0.05)。结论面对疑似糖尿病的患者,建议合用尿微量白蛋白、尿肌酐比值进行诊断,其诊断价值更高,可作为临床鉴别糖尿病肾病的重要参考依据。Objective To analyze value of combined test of urinary microalbumin and creatinine in diagnosis of diabetes nephropathy.Methods The paper chose 50 patients of suspected diabetes nephropathy in our hospital from June 1,2023 to May 31,2024 as study subjects,collected 10mL of midstream urine sample of study subjects,determined urinary microalbumin and urinary creatinine levels in laboratory,and carried out renal biopsy for 50 suspected patients,analyzed effect of urinary microalbumin,urinary creatinine and their ratio in diagnosis of diabetes nephropathy with diagnosis gold standard of renal biopsy.Results Among 50 suspected cases with renal biopsy,34 cases had diabetes nephropathy and 16 had simple diabetes.Levels of urinary microalbumin,creatinine and ratio of microalbumin to creatinine in the simple diabetes group were lower than the diabetes nephropathy group(P<0.05).Accuracy,specificity and sensitivity of ratio of urinary microalbumin to urinary creatinine was higher than single index in diagnosis of diabetes nephropathy,with statistically significant difference(P<0.05).Conclusion It is suggested to diagnose suspected diabetes patients with urinary microalbumin and urinary creatinine ratio,which has higher diagnostic value and can be used as important reference for clinical differentiation of diabetes nephropathy.

关 键 词：糖尿病肾病 尿微量白蛋白 尿肌酐 诊断价值 

分 类 号：R58[医药卫生—内分泌]