注意缺陷多动障碍儿童的多动行为与血清促甲状腺激素水平的关系  

The relationship between hyperactivity behavior in children with attention deficit hyperactivity disorder and serum level of thyroid-stimulating hormone

作　　者：黄秋玲[1] 郁峰[1] 邹小杰[1] 徐震[1] HUANG Qiuling;YU Feng;ZOU Xiaojie;XU Zhen(Department of Pediatrics,Huzhou Central Hospital,Huzhou 313000,Zhejiang,China)

机构地区：[1]湖州市中心医院儿科,浙江湖州313000

出　　处：《中国现代医生》2025年第3期13-17,共5页China Modern Doctor

摘　　要：目的探讨甲状腺功能与注意缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)儿童多动行为(hyperactivity behavior,HB)之间的关系,进一步了解导致ADHD风险增加的潜在因素,为儿童ADHD的治疗提供参考。方法选取2018年2月至2023年8月于湖州市中心医院治疗并随访的134例ADHD患儿作为研究对象,根据多动指数(hyperactivity index,HI)分为非HB组(n=71)和HB组(n=63),比较两组患儿的一般资料和常规实验室参数,通过二分类Logistic回归分析评估HB相关因素,通过Pearson直线相关分析和受试者操作特征曲线探讨HB与血清促甲状腺激素(thyroid stimulating hormone,TSH)的关系及TSH水平在区分ADHD儿童HB方面的潜在诊断价值。结果HB组患儿的乳酸、TSH水平高于非HB组,差异有统计学意义(P<0.05);TSH水平与HB独立相关,与HI得分呈正相关(r=0.668,P<0.001);TSH水平在区分ADHD儿童HB方面具有一定的价值,截断值为2.57μIU/ml(敏感度65.1%,特异性74.7%)。结论本研究揭示血清TSH水平与ADHD患儿的HB呈正相关,可用于区分ADHD儿童的HB。Objective To explore the relationship between thyroid function and hyperactivity behavior(HB)in children with attention deficit hyperactivity disorder(ADHD),and further understand the potential factors contributing to increased risk of ADHD,and provide references for the treatment of ADHD in children.Methods A total of 134 pediatric ADHD patients who were treated and followed up at Huzhou Central Hospital from February 2018 to August 2023 were selected as the research subjects.According to the hyperactivity index(HI),they were divided into non HB group(n=71)and HB group(n=63).General information and routine laboratory parameters were compared between two groups.HB-related factors were evaluated by using binary Logistic regression analysis.Finally,Pearson linear correlation analysis and receiver operating characteristic curve were used to study the relationship between HB and thyroid stimulating hormone(TSH)and the potential diagnostic value of TSH levels in distinguishing ADHD children with HB.Results The differences in lactic acid and TSH levels between two groups of cases were statistically significant,with HB group significantly higher compared to non HB group(P<0.05).Among them,TSH level was independently associated with HB and positively correlated with HI score(r=0.668,P<0.001).Additionally,TSH level had a certain value in distinguishing ADHD children with HB,with a cut-off point of 2.57μIU/ml(sensitivity was 65.1%,specificity was 74.7%).Conclusion This study revealed a positive correlation between serum TSH level and HB in children with ADHD,and it can be used to differentiate ADHD children with HB.

关 键 词：注意缺陷多动障碍 多动指数 促甲状腺激素 

分 类 号：R729[医药卫生—儿科]