维持性血液透析患者血清钙磷与血红蛋白水平及影响因素分析  

Analysis of serum calcium,phosphate,hemoglobin levels and influencing factors in maintenance hemodialysis patients

作　　者：孙福州 王誉芳 李志燕 李锋[1] 王庆芳[1] SUN Fuzhou;WANG Yufang;LI Zhiyan;LI Feng;WANG Qingfang(Department of Nephrology,Zaozhuang Municipal Hospital,Zaozhuang 277100,Shandong,China;Department of Pharmacy,Zaozhuang Municipal Hospital,Zaozhuang 277100,Shandong,China)

机构地区：[1]枣庄市立医院肾内科,山东枣庄277100 [2]枣庄市立医院药学科,山东枣庄277100

出　　处：《中国现代医生》2025年第3期40-44,共5页China Modern Doctor

摘　　要：目的分析维持性血液透析患者的血清钙、磷和血红蛋白(hemoglobin,Hb)水平及相关影响因素。方法回顾性分析维持性血液透析患者的临床资料和相关实验室检查,分析不同血清钙、磷和Hb患者的临床相关指标及达标情况,并进行血清校正钙、磷和Hb与临床指标的相关性及多重线性回归分析。结果217例维持性血液透析患者中男性115例(53.0%),平均年龄(55.88±13.54)岁。血清校正钙达标率为50.70%,血磷达标率为24.00%,Hb达标率为34.10%。多因素线性回归分析显示维持性血液透析患者的血清校正钙与碳酸氢根、Hb独立正相关;血磷与肌酐、尿素、血钾独立正相关,与年龄呈负相关;Hb与总蛋白、血清校正钙水平独立正相关,与C反应蛋白、β_(2)微球蛋白、甲状旁腺素呈负相关。结论本研究显示维持性血液透析患者的血清钙、磷和Hb控制达标率低。分析各指标的相关影响因素,利于指导并发症控制,为临床疾病管理提供参考。Objective To analyze the current status of serum calcium,phosphorus,and hemoglobin(Hb)levels in maintenance hemodialysis patients and identify related influencing factors.Methods Clinical data and related laboratory tests of maintenance hemodialysis patients were retrospective analyzed,clinical related indicators and target achievement rates among different serum calcium,phosphorus and Hb patients were analyzed,correlation and multiple linear regression analysis of serum corrected calcium,phosphorus and Hb and clinical indicators were performed.Results 217 maintenance hemodialysis patients,115(53.0%)cases were male,mean age was(55.88±13.54)years.The target achievement rates for serum corrected calcium,phosphorus,and Hb was 50.70%,24.00%,and 34.10% respectively.Multivariate linear regression analysis revealed that in maintenance hemodialysis patients,serum corrected calcium was independently positively correlated with bicarbonate and Hb;Serum phosphorus was independently positively correlated with creatinine,urea,and serum potassium,but negatively correlated with age;And Hb was independently positively correlated with total protein and serum corrected calcium,while being negatively correlated with C-reactive protein,β_(2) microglobulin,and parathyroid hormone.Conclusion The control target achievement rates for serum calcium,phosphorus,and Hb in maintenance hemodialysis patients at our center are low.Attention which should be paid to the related influencing factors of these indicators is beneficial to guide the control of complications and provide a reference for clinical disease management.

关 键 词：维持性血液透析 血清钙 血清磷 血红蛋白 影响因素 

分 类 号：R692.5[医药卫生—泌尿科学] R459.5[医药卫生—外科学]