通窍活血汤联合盐酸氟桂利嗪治疗对瘀血阻窍型椎基底动脉供血不足性眩晕患者血液流变学指标的影响  

Effect of Tongqiao Huoxue Decoction Combined with Flunarizine Hydrochloride on Hemorheological Indicators in Patients with Vertebrobasilar Insufficiency Vertigo of the Type of Blockage of Orifices by Blood Stasis

作　　者：肖春风 李建坤 肖旭 XIAO Chunfeng;LI Jiankun;XIAO Xu(Department of Internal Medicine,Zhengding County Hospital of Traditional Chinese Medicine,Shijiazhuang 050800,China)

机构地区：[1]正定县中医院内科,河北石家庄050800

出　　处：《反射疗法与康复医学》2024年第22期33-36,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨通窍活血汤联合盐酸氟桂利嗪治疗对瘀血阻窍型椎基底动脉供血不足性眩晕患者血液流变学指标的影响。方法选取2022年1月—2023年10月正定县中医院收治的78例瘀血阻窍型椎基底动脉供血不足性眩晕患者为研究对象,按随机数字表法将其分为对照组和观察组,每组39例。对照组采用盐酸氟桂利嗪胶囊治疗,观察组在对照组的基础上采用通窍活血汤治疗,两组患者均持续治疗1个月。对比两组的眩晕症状、脑动脉血流动态参数、血液流变学指标、不良反应发生情况。结果治疗后,观察组欧洲眩晕评分量表评分为(5.33±0.75)分,低于对照组的(9.81±1.06)分,差异有统计学意义(P<0.05);观察组脑动脉血峰值流速、平均血流速度均快于对照组,血管阻力指数、血管搏动指数均低于对照组,组间差异有统计学意义(P<0.05);观察组血浆黏度、全血高切黏度、全血低切黏度均低于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论瘀血阻窍型椎基底动脉供血不足性眩晕患者予以通窍活血汤联合盐酸氟桂利嗪治疗可减轻眩晕症状,改善血液流变学指标,加快脑动脉血流速度,且安全可靠。Objective To explore the impact of Tongqiao Huoxue decoction combined with flunarizine hydrochloride on the hemorheological indicators of patients with vertebrobasilar insufficiency vertigo of the type of blockage of orifices by blood stasis.Methods Seventy-eight patients with vertebrobasilar insufficiency vertigo of the type of blockage of orifices by blood stasis who were admitted to the Zhengding County Hospital of Traditional Chinese Medicine from January 2022 to October 2023 were selected as the research objects,they were divided into a control group and an observation group according to the random number table method,with 39 cases in each group.The control group was treated with flunarizine hydrochloride capsules,while the observation group was treated with Tongqiao Huoxue decoction on the basis of the treatment of the control group.Patients in both groups continued the treatment for one month.The vertigo symptoms,dynamic parameters of cerebral arterial blood flow,hemorheological indicators and the occurrence of adverse reactions of the two groups were compared.Results After treatment,the score of the European Evaluation Vertigo Scale in the observation group was(5.33±0.75)points,which was lower than(9.81±1.06)points of the control group,and the difference was statistically significant(P<0.05);the peak blood flow velocity and the average blood flow velocity of the cerebral arteries in the observation group were both faster than those in the control group,while the vascular resistance index and the vascular pulsatility index were both lower than those in the control group, and the differences between the groups were statistically significant (P<0.05);the plasma viscosity, whole blood high-shear viscosity and whole blood low-shear viscosity in the observation group were all lower than those in the control group, and the differences between the groups were statistically significant (P<0.05). There was not statistically significant difference in the incidence of adverse reactions between the two groups (P>0.0

关 键 词：椎基底动脉供血不足性眩晕 瘀血阻窍型 通窍活血汤 盐酸氟桂利嗪 血液流变学指标 

分 类 号：R441.2[医药卫生—诊断学]