HACEK组细菌感染性心内膜炎的研究进展  

Research progress on infective endocarditis caused by HACEK group bacteria

作　　者：吴琳萍 王琳[2] 陈莉媛 宋黎桥 马学霞 王苑名 苏少晨 WU Linping;WANG Lin;CHEN Liyuan;SONG Liqiao;MA Xuexia;WANG Yuanming;SU Shaochen(School of Stomatology,Lanzhou University,Lanzhou 730000,China;Department of Stomatology,The Second Hospital of Lanzhou University,Lanzhou 730030,China;Department of Stomatology,The First Hospital of Lanzhou University,Lanzhou 730013,China)

机构地区：[1]兰州大学口腔医学院,甘肃兰州730000 [2]兰州大学第二医院口腔科,甘肃兰州730030 [3]兰州大学第一医院口腔科,甘肃兰州730013

出　　处：《中国感染控制杂志》2025年第2期267-272,共6页Chinese Journal of Infection Control

基　　金：2023年甘肃省科技重大专项(23ZDFA005);兰州大学医学研究生培养创新发展项目(LZUYXCX-2022-145)。

摘　　要：HACEK组微生物(包括副流感嗜血杆菌、伴放线聚集杆菌、心杆菌属、侵蚀艾肯菌和金格杆菌)属于革兰阴性杆菌,是正常口咽菌群的组成成员,可在宿主免疫屏障受损时引起侵袭机会性感染,其中感染性心内膜炎是最严重的疾病之一。其特点是病程隐匿,存在较长时间的诊断延迟,药物治疗依赖于第三代头孢菌素。近年来,16S rRNA基因测序技术的出现与发展有望实现对该疾病的快速诊断。本文总结HACEK组细菌引起的感染性心内膜炎的主要临床特点以及研究进展,以期为临床诊疗提供借鉴意义。The HACEK group microorganisms(Haemophilus parainfluenzae,Aggregatibacter actinomycetemcomitans,Cardiobacterium spp.,Eikenella corrodens,Kingella kingae)belong to Gram-negative bacilli and are members of the normal oropharyngeal microbiota,which can cause invasive opportunistic infection when the host immune barrier is damaged,with infective endocarditis being one of the most serious diseases.HACEK endocarditis is characterized by an insidious course,prolonged delay of diagnosis,and dependence on third-generation cephalosporins for treatment.In recent years,with the emergence and development of 16S ribosomal RNA gene sequencing technique,the rapid diagnosis of this disease is expected to be achieved.This paper summarizes the main clinical characteristics and research progress of infective endocarditis caused by HACEK group bacteria,aiming to provide reference for clinical diagnosis and treatment.

关 键 词：HACEK组微生物 感染性心内膜炎 诊疗 

分 类 号：R542.42[医药卫生—心血管疾病]