急性心肌梗死患者介入治疗前后血清miR-22水平变化与其早期预后的关系  

Correlation between the changes of serum miR-22 level before and after interventional therapy and its early prognosis in patients with acute myocardial infarction

作　　者：马光宇 姜海瑞[1] 李美娜 李彩杰 张宁宁[3] MA Guangyu;JIANG Hairui;LI Meina;LI Caijie;ZHANG Ningning(Departmentof Cardiology,the Second Affiliated Hospital of Qiqihar Medical University,Heilongjiang,Qiqihar 161006,China;Department of Endocrinology,the First Affiliated Hospital of Qiqihar Medical University,Heilongjiang,Qiqihar 161006,China;Teaching and Research Section of Pathophysiology,Qiqihar Medical University,Heilongjiang,Qiqihar 161003,China)

机构地区：[1]齐齐哈尔医学院附属第二医院心内科,黑龙江齐齐哈尔161006 [2]齐齐哈尔医学院第一附属医院内分泌科,黑龙江齐齐哈尔161041 [3]齐齐哈尔医学院病理生理教研室,黑龙江齐齐哈尔161003

出　　处：《中国医药科学》2025年第2期75-78,共4页China Medicine And Pharmacy

基　　金：黑龙江省齐齐哈尔市科技计划联合引导项目(LSFGG-2023083)。

摘　　要：目的探究急性心肌梗死患者介入治疗前后血清miR-22水平变化及其与早期预后的关系。方法前瞻性选取2023年1—12月于齐齐哈尔医学院附属第二医院接受介入治疗的62例急性心肌梗死患者为研究对象,根据患者早期预后情况的不同分为预后良好组和预后不良组,采用单因素及多因素logistic回归分析两组患者介入前后血清miR-22水平变化及早期预后的相关影响因素。结果62例患者经介入治疗后,43例(69.35%)早期预后良好,19例(30.65%)患者早期预后情况不良。两组患者治疗后血清miR-22均较治疗前降低,且预后良好组患者的血清miR-22水平显著低于预后不良组。多因素logistic回归分析显示,发病至入院时间(OR=2.533,95%CI:1.099~5.839,P=0.029)、miR-22水平(OR=9.686,95%CI:1.398~67.124,P=0.022)是影响急性心肌梗死患者介入治疗后早期预后的独立危险因素。结论急性心肌梗死患者介入治疗后血清miR-22相对表达水平是影响急性心肌梗死患者介入治疗后早期预后的独立危险因素,对患者早期预后结果有较好的预测作用。Objective To investigate the correlation between the changes of serum miR-22 level before and after intervention and its early prognosis in patients with acute myocardial infarction.Methods A total of 62 patients with acute myocardial infarction who received interventional therapy in the Second Affiliated Hospital of Qiqihar Medical College from January to December 2023 were prospectively selected as the research objects,and they were divided into the good prognosis group and the poor prognosis group according to patient’s early prognosis situations.Univariate and multivariate logistic regression were used to analyze the changes of serum miR-22 levels before and after intervention and the related impacting factors of early prognosis.Results After interventional therapy for a total of 62 patients,43 patients(accounting for 69.35%)had good early prognosis,while 19 patients(accounting for 30.65%)had poor early prognosis.Serum miR-22 in both groups decreased after treatment,and the serum miR-22 level in patients with good prognosis was significantly lower than that in patients with poor prognosis.Multivariate logistic regression analysis showed that the time from onset to admission(OR=2.533,95%CI:1.099-5.839,P=0.029)and the level of miR-22(OR=9.686,95%CI:1.398-67.124,P=0.022)were independent risk factors impacting the early prognosis of patients with acute myocardial infarction after interventional therapy.Conclusion The relative expression level of serum miR-22 in patients with acute myocardial infarction after interventional therapy is an independent risk factor impacting the early prognosis of patients with acute myocardial infarction after interventional therapy,which has a good predictive effect on the early prognosis of patients.

关 键 词：miR-22 急性心肌梗死 介入治疗 早期预后 

分 类 号：R542.22[医药卫生—心血管疾病]