北京市垂杨柳医院患者γ-干扰素释放试验的临床应用研究  

Clinical application research of interferon gamma release assay of patients in Chuiyangliu Hospital of Beijing City

作　　者：王俊文[1] 于波 刘薇[1] 高慧双 田淑琳 路璐[1] 朱雅迪 宁永忠 WANG Junwen;YU Bo;LIU Wei;GAO Huishuang;TIAN Shulin;LU Lu;ZHU Yadi;NING Yongzhong(Department of Clinical Laboratory,Chuiyangliu Hospital of Beijing City,Beijing 100022,China;Graduate School of Hebei Medical University,Hebei,Shijiazhuang 050017,China)

机构地区：[1]北京市垂杨柳医院检验科,北京100022 [2]河北医科大学研究生院,河北石家庄050017

出　　处：《中国医药科学》2025年第2期134-137,共4页China Medicine And Pharmacy

基　　金：北京市科技攻关计划(首发2021-1G-2032)。

摘　　要：目的了解北京市垂杨柳医院就诊患者γ-干扰素释放试验(IGRA)检测结核分枝杆菌潜伏感染临床特征。方法收集北京市垂杨柳医院2018年1月至2022年12月的8736例患者IGRA检测结果,分析患者潜在感染状况。结果就诊患者IGRA总阳性率为17.26%(1508/8736),2018—2022年逐年比较,差异有统计学意义(χ^(2)=13.706,P=0.008)。男性组IGRA总阳性率高于女性组,差异有统计学意义(χ^(2)=5.168,P=0.012)。4个年龄组阳性率比较,差异有统计学意义(χ^(2)=6.951,P=0.001),年龄越大IGRA阳性率越低。结论北京市垂杨柳医院就诊患者结核杆菌潜伏感染相对较高,有逐年增高趋势,提示应加强人员监测力度,提高结核分枝杆菌潜伏感染的早期诊断率。Objective To understand the clinical characteristics of detecting latent infection of Mycobacterium tuberculosis by interferon gamma release assay(IGRA)of patients in Chuiyangliu Hospital of Beijing City.Methods The IGRA test results of 8736 patients in Chuiyangliu Hospital of Beijing City from January 2018 to December 2022 were collected,and the potential infection status of patients was analyzed.Results The total positive rate of IGRA in visiting patients was 17.26%(1508/8736),and the difference was statistically significant from 2018 to 2022(χ^(2)=13.706,P=0.008).The total positive rate of IGRA of male group was higher than the female group,with statistically significant difference(χ^(2)=5.168,P=0.012).The positive rates of IGRA of the 4 age groups were compared,with statistically significant difference(χ^(2)=6.951,P=0.001).The older the age group,the lower the positive rate.Conclusion The latent infection of Mycobacterium tuberculosis in patients admitted to Chuiyangliu Hospital of Beijing City is relatively high,which tends to increase year by year,suggesting that personnel monitoring should be strengthened to improve the early diagnosis rate of latent infection of Mycobacterium tuberculosis.

关 键 词：Γ-干扰素释放试验 潜伏结核感染 结核分枝杆菌 结核病 结核菌素皮肤试验 

分 类 号：R52[医药卫生—内科学]