低频重复经颅磁刺激联合A型肉毒毒素治疗梅杰综合征的疗效研究  

Clinical efficacy of low-frequency repetitive transcranial magnetic stimulation combined with botulinum toxin type A in the treatment of patients with Meige syndrome

作　　者：雷四英[1] 彭铎 LEI Siying;PENG Duo(Department of Neurology,Lishui People's Hospital,Lishui,Zhejiang 323000,China;Department of Clinical Laboratory,Lishui People's Hospital,Lishui,Zhejiang 323000,China)

机构地区：[1]丽水市人民医院神经内科,浙江丽水323000 [2]丽水市人民医院检验科,浙江丽水323000

出　　处：《医药前沿》2025年第5期15-18,共4页Journal of Frontiers of Medicine

基　　金：浙江省医药卫生科研面上项目(2020KY1074)。

摘　　要：目的评估低频重复经颅磁刺激(rTMS)联合A型肉毒毒素治疗梅杰综合征的临床效果。方法选取2019年12月—2021年12月于丽水市人民医院神经内科就诊的梅杰综合征患者50例,按照随机数字表法分为A型肉毒毒素组(BTX组)和低频rTMS联合A型肉毒毒素组(rTMS+BTX组),各25例。BTX组给予注射用A型肉毒毒素,rTMS+BTX组在注射A型肉毒毒素的同时给予低频rTMS治疗。观察两组患者的起效时间,通过Jankovic评定量表(JRS)和眼睑痉挛残疾指数(BSDI)综合评估疗效。结果rTMS+BTX组起效时间短于BTX组,差异有统计学意义(P<0.05);两组第4、12周JRS、BSDI评分较治疗前均降低(P<0.05),且第4周时rTMS+BTX组BSDI评分低于BTX组(P<0.05)。结论低频rTMS联合A型肉毒毒素治疗梅杰综合征起效快,患者症状改善明显,不良反应少。Objective To evaluate the clinical efficacy of low-frequency repetitive transcranial magnetic stimulation(rTMS)combined with botulinum toxin type A in the treatment of patients with Meige syndrome.Methods A total of 50 patients with Meige syndrome who visited Department of Neurology in Lishui People's Hospital from December 2019 to December 2021 were selected and divided into botulinum toxin type A group(BTX group)and low-frequency repetitive transcranial magnetic stimulation+botulinum toxin type A group(rTMS+BTX group)by random number table method,with 25 cases in each group.The BTX group was given botulinum toxin type A for injection,while the rTMS+BTX group was given low-frequency rTMS treatment and botulinum toxin type A for injection simultaneously.In the two groups,the onset time was observed,and the efficacy was synthetically evaluated by Jankovic Rating Scale(JRS)and Blepharospasm Disability Index(BSDI).Results The onset time in rTMS+BTX group was shorter than that in BTX group,and the difference was statistically significant(P<0.05).The scores of JRS and BSDI after treatment for 4 and 12 weeks were lower than those before treatment in the two groups(P<0.05).After treatment for 4 weeks,the BSDI score in rTMS+BTX group were lower than that in BTX group(P<0.05).Conclusions Low-frequency repetitive transcranial magnetic stimulation combined with botulinum toxin type A can rapid onset and significantly improve the clinical symptoms with rapid less adverse effects in treatment of patients with Meige syndrome.

关 键 词：梅杰综合征 肉毒毒素 重复经颅磁刺激 低频 疗效 不良反应 

分 类 号：R378[医药卫生—病原生物学]