响应面-满意度函数法优选当归补血汤水提工艺  

Optimization of Water Extraction Process for Danggui Buxue Decoction by Response Sur⁃face-Satisfaction Function Method

作　　者：王维 陈静 侯少平[3] 奚军伟 WANG Wei;CHEN Jing;HOU Shaoping;XI Junwei(Shaanxi Provincial Drug and Vaccine Inspection Center,Xi'an,Shaanxi,China 710065;Shaanxi Provincial ADR Monitoring Center,Xi'an,Shaanxi,China 710065;Shaanxi University of International Trade&Commerce,Xi'an,Shaanxi,China 712046)

机构地区：[1]陕西省药品和疫苗检查中心,陕西西安710065 [2]陕西省药品不良反应监测中心,陕西西安710065 [3]陕西国际商贸学院,陕西咸阳712046

出　　处：《中国药业》2025年第4期66-70,共5页China Pharmaceuticals

基　　金：国家科技部重大新药创制项目[2018ZX19721005-004-007]。

摘　　要：目的 优选当归补血汤的水提工艺。方法 以浸泡时间、提取时间、提取温度、液料比为考察因素,以多糖、藁本内酯提取率的满意度为评价指标,采用响应面-满意度函数法优选煎剂最优水提工艺,并验证。结果 最佳水提工艺为,浸泡时间21 min,提取时间35 min,提取温度57℃,液料比60 mL/g。该条件下多糖提取率为2.865%、藁本内酯提取率为0.014 6%,满意度为96.07%,与系统预测值(96.42%)较接近。结论 该法稳定可行,可为当归补血汤的开发与应用提供参考。Objective To optimize the water extraction process of Danggui Buxue Decoction.Methods The response surface-satisfaction function method was used to optimize the water extraction process of Danggui Buxue Decoction with soaking time,extraction time,extraction temperature,and ratio of liquid to material as the investigation factors,and with the satisfaction rate of polysaccharide and ligustilide extraction as the evaluation indicator.Then the verification test was conducted.Results The optimal water extraction process was as follows:the soaking time was 21 min,the extraction time was 35 min,the extraction temperature was 57℃,and the ratio of liquid to material was 60 mL/g.Under these conditions,the polysaccharide extraction rate was 2.865%,the ligustilide extraction rate was 0.0146%,and the satisfaction rate was 96.07%,which was close to the predicted value(96.42%).Conclusion This method is stable and feasible,which can provide reference for the development and application of Danggui Buxue Decoction.

关 键 词：当归补血汤 水提工艺 响应面-满意度函数法 

分 类 号：R943[医药卫生—药剂学]