非奈利酮临床应用和不良反应研究进展  

Research progress on the clinical application and adverse reactions of finerenone

作　　者：宋欣妮 董志强 张燕[2] SONG Xinni;DONG Zhiqiang;ZHANG Yan(Baotou Medical College of Inner Mongolia Scientific and Technological University,Baotou 014040,China;不详)

机构地区：[1]内蒙古科技大学包头医学院,内蒙古包头014040 [2]内蒙古科技大学包头医学院第一附属医院药剂部,内蒙古包头014010

出　　处：《中国处方药》2025年第3期93-96,共4页Journal of China Prescription Drug

基　　金：内蒙古自治区教育科学研究“十四五”规划课题项目(NGJGH2021220)。

摘　　要：非奈利酮是一种新型的非甾体选择性盐皮质激素受体拮抗剂,可通过抗炎和抗纤维化、减轻蛋白尿、调控血压等多重机制延缓肾脏疾病的进展并减少心血管事件的发生率,目前临床上主要用于治疗难治性高血压、糖尿病肾病和心力衰竭等疾病。本文通过查阅文献,从非奈利酮的临床应用、不良反应和用药注意等方面进行综述,旨在更充分地认识该药,为临床应用提供新思路。Finerenone is a novel non-steroidal selective mineralocorticoid receptor antagonist.Multiple mechanisms such as antiinflammatory and anti-fibrotic,reduced proteinuria,and blood pressure regulation can delay the progression of kidney disease and reduce the incidence of cardiovascular events.At present,it is mainly used in clinical treatment for refractory hypertension,diabetic nephropathy and heart failure.This auticle reviews the clinical application,adverse reactions and medication attention of finerenone by consulting the literature.It aims to have a fuller understanding of the drug and provide new ideas for clinical application.

关 键 词：非奈利酮 盐皮质激素受体拮抗剂 临床应用 不良反应 

分 类 号：R969.3[医药卫生—药理学]