基于加权TOPSIS法的药学干预对抗肿瘤药物点评合理性的影响  

Influence of Pharmaceutical Intervention Based on Weighted TOPSIS Method on the Rationality of Antitumor Drug Reviews

作　　者：曹芳 杨金有 申永林 叶茜 Cao Fang;Yang Jinyou;Shen Yonglin;Ye Xi(Department of Pharmacy,Southern Central Hospital of Yunnan Province,Gejiu,Yunnan 661199,China;Department of Hematology,Southern Central Hospital of Yunnan Province,Gejiu,Yunnan 661199,China)

机构地区：[1]云南省滇南中心医院药学部,云南个旧661199 [2]云南省滇南中心医院肿瘤血液科,云南个旧661199

出　　处：《大理大学学报》2025年第2期20-24,共5页Journal of Dali University

摘　　要：目的:采用加权TOPSIS法对某院抗肿瘤药物使用情况进行专项点评,为其合理应用提供参考。方法:采用随机抽样法从某院临床药学管理系统中随机抽取2022年7-12月(干预前)、2023年1-6月(干预后)使用抗肿瘤药物的出院患者病历各270份,采用加权TOPSIS法对抗肿瘤药物使用合理性进行评价,对比药学干预前后抗肿瘤药物使用合理情况。结果:与干预前相比,干预后抗肿瘤药物使用合理情况显著提升(P<0.05),肿瘤分期情况、化疗前ECOG或KPS评分、越级开具、溶媒等7项评价指标评分显著提高(P<0.05),无指征使用质子泵抑制剂、预防的疗程不适宜以及同时使用2种5-羟色胺3受体拮抗剂等问题均显著减少(P<0.05);干预前没有使用神经激肽-1(NK-1)受体拮抗剂的病例,干预后使用NK-1受体拮抗剂者23例(占8.52%)。结论:基于加权TOPSIS法的药学干预,可促进抗肿瘤药物的合理使用。Objective:Weighted TOPSIS method was adopted to conduct a special review on the use of antitumor drugs in a hospital and to provide reference for their rational application.Methods:A random sampling method was used to randomly select medical records of discharged patients who used antitumor drugs from the clinical pharmacy management system of a hospital from July to December 2022(before intervention)and January to June 2023(after intervention).270 medical records were selected for each time period.The weighted TOPSIS method was used to evaluate the rationality of the use of antitumor drugs,and the rational use of antitumor drugs before and after pharmaceutical intervention was compared.Results:Compared with that before intervention,the rational use of antitumor drugs was significantly improved after the intervention(P<0.05).The scores of seven evaluation indicators,including tumor stage,ECOG or KPS score before chemotherapy,skip-level prescription and solvent,were significantly improved(P<0.05).Problems such as the use of proton pump inhibitors without indication,inappropriate duration of prophylaxis,and simultaneous use of two 5-hydroxytryptamine 3 receptor antagonist were significantly reduced(P<0.05).There were no medical records of using neurokinin-1(NK-1)receptor antagonist before the intervention,while 23 cases(accounting for 8.52%)used NK-1 receptor antagonist after the intervention.Conclusion:Pharmaceutical intervention based on weighted TOPSIS method can promote the rational use of antitumor drugs.

关 键 词：加权TOPSIS法 药学干预 抗肿瘤药物 合理性分析 

分 类 号：R979.1[医药卫生—药品]