盐酸伊伐布雷定联合左西孟旦治疗急性心肌梗死伴心力衰竭患者的效果及安全性观察  

Observation of the Efficacy and Safety of Ivabradine Hydrochloride Combined with Levosimendan in the Treatment of Patients with Acute Myocardial Infarction and Heart Failure

作　　者：刘莹 LIU Ying(Department of Emergency,Shandong Medical College Affiliated Hospital,Linyi 276000,China;Department of Cardiovascular Medicine,Linyi Dongshan Hospital,Linyi 276000,China)

机构地区：[1]山东医学高等专科学校附属医院急诊科,山东临沂276000 [2]临沂东山医院心血管内科,山东临沂276000

出　　处：《反射疗法与康复医学》2024年第21期98-101,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨盐酸伊伐布雷定联合左西孟旦治疗急性心肌梗死(AMI)伴心力衰竭(HF)患者的效果及安全性。方法回顾性分析2020年5月—2023年5月临沂东山医院收治的80例AMI伴HF患者的病例资料,按治疗方案的不同将其分为对照组和观察组,各40例。两组患者均行PCI术及常规治疗,对照组采用左西孟旦治疗,观察组采用左西孟旦联合盐酸伊伐布雷定治疗。比较两组的临床疗效、心功能指标、血压及心率、心血管不良事件、不良反应发生情况。结果观察组治疗总有效率为95.00%,高于对照组的72.50%,差异有统计学意义(P<0.05)。治疗后,观察组心排血量、左心室射血分数水平均高于对照组,左心室舒张末期容积小于对照组,组间差异有统计学意义(P<0.05);观察组舒张压、收缩压、平均动脉压均低于对照组,心率慢于对照组,组间差异有统计学意义(P<0.05)。观察组心血管不良事件发生率为2.50%,低于对照组的7.50%,差异有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论在AMI伴HF患者中采用盐酸伊伐布雷定联合左西孟旦治疗的疗效较好,可促进血压、心率及心功能改善,降低心血管不良事件发生率,且安全性高。Objective Exploring the efficacy and safety of ivabradine hydrochloride combined with levosimendan in the treatment of patients with acute myocardial infarction(AMI)and heart failure(HF).Methods Retrospective analysis of case data of 80 patients with AMI and HF admitted to Linyi Dongshan Hospital from May 2020 to May 2023,according to different treatment plans,they were divided into a control group and an observation group,with 40 cases in each group,both groups of patients underwent PCI and conventional treatment.The control group was treated with levosimendan,while the observation group was treated with levosimendan combined with ivabradine hydrochloride.Compare the clinical efficacy,cardiac function indicators,blood pressure and heart rate,cardiovascular adverse events and occurrence of adverse reactions between two groups.Results The total effective rate of the observation group was 95.00%,which was higher than the 72.50%of the control group,the difference was statistically significant(P<0.05).After treatment,the cardiac output and left ventricular ejection fraction levels in the observation group were higher than those in the control group,and the left ventricular end diastolic volume was smaller than that in the control group,the differences between the groups were statistically significant P<0.05);the diastolic blood pressure,systolic blood pressure,and mean arterial pressure in the observation group were than those of the control group,and heart rate was slower than that in the control group,the differences between the groups were statistically significant(P<0.05).The incidence of cardiovascular adverse events in the observation group was 2.50%,which was lower than 7.50%in the control group,the difference was statistically significant(P<0.05).Comparison of adverse reaction rates between two groups,the difference was not statistically significant(P>0.05).Conclusion The ivabradine hydrochloride combined with levosimendan has a good therapeutic effect in patients with AMI and HF,which can promote the improve

关 键 词：急性心肌梗死 心力衰竭 盐酸伊伐布雷定 左西孟旦 临床效果 

分 类 号：R541[医药卫生—心血管疾病]