老年重症肺炎患者凝血功能指标变化及意义  

Changes and significance of coagulation function indicators in elderly patients with severe pneumonia

作　　者：刘英超[1] 张丽娜 张秋月 李震 田佳 LIU Yingchao;ZHANG Lina;ZHANG Qiuyue;LI Zhen;TIAN Jia(Department of Clinical Laboratory,the Second People’s Hospital of Liaocheng,Linqing 252600,Shandong,China;Department of Research Management,the Second People’s Hospital of Liaocheng,Linqing 252600,Shandong,China;Department of Pathology,the Second People’s Hospital of Liaocheng,Linqing 252600,Shandong,China)

机构地区：[1]聊城市第二人民医院检验科,山东临清252600 [2]聊城市第二人民医院科研管理科,山东临清252600 [3]聊城市第二人民医院病理科,山东临清2526001

出　　处：《中国现代医生》2025年第4期36-39,共4页China Modern Doctor

基　　金：山东省聊城市重点研发计划政策引导类项目(2023YD48)。

摘　　要：目的探讨老年重症肺炎患者凝血功能相关指标水平变化的临床意义。方法选取2022年1月至2023年12月聊城市第二人民医院收治的老年重症肺炎患者127例纳入观察组,选取同期收治的普通肺炎患者135例纳入对照组,比较两组患者入院24h内的凝血功能指标[血小板(platelet,PLT)、凝血酶原时间(prothrombin time,PT)、纤维蛋白原(fibrinogen,FIB)、活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、凝血酶时间(thrombin time,TT)、D-二聚体(D-dimer,D-D)]。结果观察组患者的年龄显著大于对照组,吸烟史、有基础疾病及基础疾病≥2种的占比均显著高于对照组(P<0.05)。观察组患者的PT、D-D阳性率显著高于对照组(P<0.05);观察组患者的PT、TT显著长于对照组,D-D水平显著高于对照组,PLT水平显著低于对照组(P<0.05)。结论重症肺炎患者常发生凝血功能异常,开展凝血功能相关指标检测对评估患者病情具有重要意义。Objective To explore the clinical significance of changes in coagulation function related indexes in elderly patients with severe pneumonia.Methods A total of 127 elderly patients with severe pneumonia admitted to the Second People’s Hospital of Liaocheng from January 2022 to December 2023 were included in observation group,and 135 patients with common pneumonia admitted during the same period were included in control group.The indexes of coagulation function[platelet(PLT),prothrombin time(PT),fibrinogen(FIB),activated partial thromboplastin time(APTT),thrombin time(TT),D-dimer(D-D)]within 24h after admission were compared between two groups.Results The age of patients in observation group was significantly higher than that in control group,and the proportion of smoking history,underlying disease and underlying disease≥2 was significantly higher than that in control group(P<0.05).The positive rates of PT and D-D in observation group were significantly higher than those in control group(P<0.05).PT and TT in observation group were significantly longer than control group,D-D level was significantly higher than that in control group,PLT level was significantly lower than that in control group(P<0.05).Conclusion Patients with severe pneumonia often have abnormal coagulation function,and the detection of related indexes of coagulation function is of great significance to evaluate the condition of patients.

关 键 词：重症肺炎 凝血功能 纤维蛋白原 D-二聚体 血小板 

分 类 号：R563.1[医药卫生—呼吸系统]