高嘌呤饮食对金黄地鼠血脂变化和病理损伤的影响  

Effects of high-purine diet on blood lipid changes and pathological lesion in golden hamsters

作　　者：贺亮 李庆香子 李锐[2] HE Liang;LI Qingxiangzi;LI Rui(Institute of Animal Husbandry and Veterinary Science,Zhejiang Academy of Agricultural Sciences,Hangzhou 310021,China;Institute of Agro-Product Safety and Nutrition,Zhejiang Academy of Agricultural Sciences,Hangzhou 310021,China)

机构地区：[1]浙江省农业科学院畜牧兽医研究所,浙江杭州310021 [2]浙江省农业科学院农产品质量安全与营养研究所,浙江杭州310021

出　　处：《浙江农业学报》2025年第1期24-31,共8页Acta Agriculturae Zhejiangensis

基　　金：浙江省基础公益研究计划(LTGD23C040006)。

摘　　要：通过高嘌呤饮食和尿酸酶抑制剂氧嗪酸钾联合诱导金黄地鼠高尿酸血症,检测机体血糖血脂指标并观察肾脏组织病理变化,探讨高嘌呤饮食对金黄地鼠血脂变化和肝肾损伤的影响。结果表明,高嘌呤饮食诱导下金黄地鼠体重和肝脏指数无显著变化,12%酵母膏、0.25%腺嘌呤分别联合2%氧嗪酸钾饲喂均导致金黄地鼠血清尿酸水平显著升高,但血清尿酸升高与血糖血脂代谢紊乱相关性不强;尿酸升高导致金黄地鼠肾脏肿大,肾脏指数显著升高,呈现典型高尿酸血症的肾脏病理损伤特征。符合人类脂代谢特征的金黄地鼠具有良好的高尿酸血症动物模型开发前景。Increases of serum uric acid in golden hamsters were induced by the combination of high-purine diet and uric acid inhibitor potassium oxonate.Serum glucose,lipid changes and histopathological changes of kidney were detected,and the effects of high-purine diet on the changes of serum lipids and liver and kidney injury of golden hamster were investigated.The results showed that there was no significant change in the body weight and liver index of golden hamsters with high-purine diet,and the application of 12%yeast and 0.25%adenine combined with 2%potassium oxonate led to a significant increase in serum uric acid level,but the correlation between elevated serum uric acid and blood glucose and lipid metabolism disorders was not strong.Elevated uric acid leads to renal enlargement,significantly increased renal index,and renal pathological injury characteristic of typical hyperuricemia.The golden hamster with human lipid metabolism characteristics have good prospects for the development of animal models of hyperuricemia.

关 键 词：金黄地鼠 尿酸 血脂 肾损伤 

分 类 号：S859[农业科学—临床兽医学]