细胞焦亡在乳腺癌治疗中的机制及潜在应用策略  

Mechanism and potential application strategies of pyroptosis in breast cancer treatment

作　　者：冉亚琴 陈曦[2] 谢晏讷 袁军 Ran Yaqin;Chen Xi;Xie Yanne;Yuan Jun(School of Medical Laboratory Science,Guizhou Medical University,Guiyang 550004,Guizhou Province,China;Department of Laboratory Medicine,Jinyang Hospital Affiliated to Guizhou Medical University,Guiyang 550081,Guizhou Province,China)

机构地区：[1]贵州医科大学医学检验学院,贵州省贵阳市550004 [2]贵州医科大学附属金阳医院检验科,贵州省贵阳市550081

出　　处：《中国组织工程研究》2025年第36期7880-7888,共9页Chinese Journal of Tissue Engineering Research

基　　金：贵州省科学技术厅项目(黔科合基础[2019]1004号),项目负责人:袁军;贵阳市科技计划项目(筑科合同[2019]9-9-2号),项目负责人:袁军。

摘　　要：背景:众多研究指出细胞焦亡在肿瘤进展中扮演着关键角色。近年来研究显示,细胞焦亡与乳腺癌发生、发展和治疗有着不可忽视的联系,开发有效的细胞焦亡治疗策略已成为乳腺癌治疗领域的研究热点。目的:综合分析细胞焦亡的机制,探究细胞焦亡在乳腺癌中的抗肿瘤作用以及在临床治疗中的潜在应用价值。方法:以“pyroptosis,breast cancer,inflammasome,gasdermin,caspase,drug resistance,treatment”为英文检索词,检索PubMed数据库建库至2024年8月发表的文献。通过阅读文题和摘要进行初步筛选,排除与此次研究内容相关性差、信息陈旧或观点重复且缺乏权威性的文献,最后纳入121篇文献进行综述。结果与结论:细胞焦亡是一种特殊的程序性细胞死亡方式,它通过激活Gasdermin家族蛋白来执行,在乳腺癌治疗中显示出潜在的应用价值。长期或不当的治疗可导致肿瘤细胞对药物产生耐药性,细胞焦亡机制的研究有助于克服耐药性缺陷。细胞焦亡能够触发免疫原性细胞死亡,促进肿瘤特异性抗原的释放,进而激活免疫系统,提高其对肿瘤细胞的识别和清除能力。细胞焦亡相关基因表达水平可作为乳腺癌预后指标,有助于评估患者的治疗反应和生存期。细胞焦亡机制研究可为乳腺癌治疗提供新的策略,如靶向诱导焦亡的药物和治疗方法,有助于实现乳腺癌个体化治疗方案。s,literature with poor relevance to the research content,outdated information,repeated views,and lack of authority was excluded.Finally,121 articles were included for review.RESULTS AND CONCLUSION:Pyroptosis is a special form of programmed cell death that is carried out by the activation of the gasdermin family of proteins,showing potential application value in the treatment of breast cancer.Long-term or improper treatment can lead to drug resistance in cancer cells;research on the mechanism of pyroptosis helps to overcome resistance deficiencies.Pyroptosis can trigger immunogenic cell death,promoting the release of tumor-specific antigens,thereby activating the immune system and enhancing its ability to recognize and clear tumor cells.The expression levels of pyroptosis-related genes can serve as prognostic indicators for breast cancer,helping to assess patients’treatment responses and survival periods.Research on the mechanisms of pyroptosis can provide new strategies for the treatment of breast cancer,such as targeted drugs and therapeutic methods that induce pyroptosis,contributing to the realization of personalized treatment plans for breast cancer.

关 键 词：细胞焦亡 乳腺癌 炎症小体 Gasdermin家族蛋白 caspase家族蛋白 预后价值 工程化组织构建 

分 类 号：R459.9[医药卫生—治疗学] R319[医药卫生—临床医学] R737.1