蒸汽渗透膜分离在医药化工领域的研究进展  

Research progress of vapor permeation membrane separation in pharmaceutical and chemical industry

作　　者：刘琴 王燕 吴思远 李万程 吴波 李传润 LIU Qin;WANG Yan;WU Siyuan;LI Wancheng;WU Bo;LI Chuanrun(Pharmaceutical Engineering Technology Research Center,School of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,China;Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application,Hefei 230012,China)

机构地区：[1]安徽中医药大学药学院,制药工程技术研究中心,合肥230012 [2]安徽省药物制剂技术与应用重点实验室,合肥230012

出　　处：《膜科学与技术》2025年第1期185-196,共12页Membrane Science and Technology

基　　金：国家重点研发计划项目(2022YFB3805100);国家自然科学基金项目(22478007);安徽省高校自然科学研究重点项目(2023AH050728)。

摘　　要：蒸汽渗透是近年来新型的膜分离技术之一.混合物以蒸汽形态进料,由化学梯度(压力、温度)为驱动力,利用各组分在膜内溶解和扩散性能的差异实现混合物分离.蒸汽渗透膜分离过程膜直接与蒸汽接触,污染小,不仅简化了工艺流程,而且还减少了能源消耗.操作简单,能与其他分离技术如精馏、吸附等有效结合,形成集成化的分离系统,提高整体分离效率和选择性.目前蒸汽渗透工业设备能实现醇类、醚类、酮类、酯类、烃类等体系脱水,收率大于99%;蒸汽渗透与水解反应耦合,乳酸乙酯的转化率近100%;故在石油化工、中医药、水处理等工业领域中有广阔的应用前景.本文探讨了常用的蒸汽渗透膜材料,概括了蒸汽渗透膜分离技术的应用现状,归纳了蒸汽渗透膜耦合工艺的价值,展望了蒸汽渗透膜分离技术的前景.为蒸汽渗透膜分离技术研究提供参考,以期最终实现蒸汽渗透膜在医药化工领域的高效综合利用.Vapor permeation is one of the new membrane separation technologies in recent years.Mixture in the form of vapor feed,by the chemical gradient(pressure,temperature)as the driving force,the use of each component in the membrane dissolution and diffusion properties of the difference between the membrane to achieve the separation of the mixture of membrane technology.Vapor permeation membrane separation process is directly in contact with vapor,pollution is small,not only simplifies the process flow,but also reduces energy consumption.Simple operation can be effectively combined with other separation technologies such as distillation,adsorption,etc.,to form an integrated separation system to improve the overall separation efficiency and selectivity.At present,vapor permeation industrial equipment can realize the dehydration of alcohols,ethers,ketones,esters,hydrocarbons and other systems,with a yield of more than 99%.Vapor permeation coupled with hydrolysis reaction;the conversion rate of ethyl lactate was nearly 1oo%.Therefore,in the petrochemical industry,traditional Chinese medicine,water treatment and other industrial fields have broad application prospects.In this paper,commonly used vapor permeation membrane materials were discussed.The current status of the application of vapor permeation membrane separation technology was summarized.The value of the vapor permeation membrane coupling process was summarized;the prospects of the vapor permeation membrane separation technology were outlook.To provide reference for the research of steam permeation membrane separation technology,with a view to ultimately realizing the efficient comprehensive utilization of vapor permeation membrane in the field of pharmaceutical and chemical industry.

关 键 词：膜 蒸汽渗透 气体 混合物 分离 

分 类 号：TQ028.8[化学工程]