调控ICC-小胶质细胞焦亡交互“异病同治”GERD共病抑郁症的可行性分析  

Feasibility analysis of regulating Icc⁃microglial Pyroptosis interaction in comorbidity of GERD and depression through"Same Treatment for Different Diseases"

作　　者：陈南 杨成宁 王宇青 罗佐媚 谢胜[2] 刘礼剑[2] 黎丽群 CHEN Nan;YANG Chengning;WANG Yuqing;LUO Zuomei;Xie Sheng;Liu Lijian;LI Liqun(Graduate School of Guangxi University of Chinese Medicine,Nanning 530001,China;First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530001,China)

机构地区：[1]广西中医药大学研究生学院,广西南宁530001 [2]广西中医药大学第一附属医院,广西南宁530001

出　　处：《海南医科大学学报》2025年第4期298-307,共10页Journal of Hainan Medical University

基　　金：广西自然科学基金项目(2024GXNSFAA999154);国家自然科学基金资助项目(82460915、82160877、82260900);国家中医药传承创新中心建设项目([发改办社会2022]366号);国家中医药管理局高水平重点学科建设项目-中医养生学科(zyyzdxk-2023167)。

摘　　要：胃食管反流病(GERD)与抑郁症发病率均高,二者常共病存在,显著增加临床治疗难度,明确其共同病机是提高疗效的关键。已知食管ICC与小胶质细胞焦亡介导的炎症反应分别与GERD、抑郁症密切相关,受NLRP3炎症小体调控,但其是否介导二者焦亡而导致GERD共病抑郁仍未知。故本文旨在探索二者共病的病机本质,为其有效“异病同治”GERD共病抑郁症提高新思路及新方法,为中药复方奠定理论依据,以期提高临床疗效。The incidence of gastroesophageal reflux disease(GERD)and depression are both high,and the comorbidities of the two often exist,which significantly increases the difficulty of clinical treatment.Identifying the common pathogenesis is the key to improve the curative effect.It is known that esophageal ICC and microglia pyroptosis mediated inflammation are closely related to GERD and depression,respectively,and are regulated by the NLRP3 inflammatome.However,whether they mediate pyroptosis of the cells and lead to the comorbidities of GERD depression remains unknown.Therefore,the purpose of this paper is to explore the pathogenesis of the two comorbid depression,improve new ideas and new methods for the effective"co‑treatment of different diseases"of GERD comorbid depression,and lay a theoretical basis for traditional Chinese medicine compound,in order to improve clinical efficacy.

关 键 词：胃食管反流病共病抑郁症 细胞焦亡 NLRP3炎症小体 CAJAL间质细胞 小胶质细胞 

分 类 号：R259[医药卫生—中西医结合] R277.7[医药卫生—中医内科学]