聚丙烯酰胺型双网络结构水凝胶制备及药物包载应用  

Preparation and Drug Delivery Applications of Polyacrylamide-based Double Network Hydrogels

作　　者：李远华 朱小龙 庄佳燕 李节 李铭龙 LI Yuanhua;ZHU Xiaolong;ZHUANG Jiayang;LI Jie;LI Minglong(School of Chemistry and Material Engineering,Huizhou University,Huizhou,516007,Guangdong,China)

机构地区：[1]惠州学院化学与材料工程学院,广东惠州516007

出　　处：《惠州学院学报》2024年第6期53-58,共6页Journal of Huizhou University

基　　金：广东省大学生创新训练项目(S202310577058);惠州学院博士科研启动项目(2020JB030)。

摘　　要：针对传统N-异丙基丙烯酰胺(NIPAM)水凝胶在机械强度、自修复能力以及药物运输储存方面的局限性,提出一种新型的双网络结构NIPAM型多功能水凝胶。该水凝胶采用NIPAM纳米粒子作为模板,通过2步聚合工艺制备而成。研究重点探讨了聚合时间和NIPAM单体浓度对水凝胶的温敏性、溶胀比、自修复性能以及亚甲基蓝的包载和释放特性的影响。实验结果表明,所得水凝胶展现出纳米多孔结构,其低临界溶解温度(LCST)为32℃,具备可控的溶胀性能,并能够实现自修复。此外,水凝胶对亚甲基蓝的包载效率达到53%,释放效率为20%,显示出其在药物小分子的储存与运输领域具有潜在的应用前景。Traditional N-isopropylacrylamide(NIPAM)hydrogels have limitations in terms of mechanical strength and self-healing ability,which restrict their applications in drug transport and storage.In this study,we propose a dual-network structure NIPAM hydrogel by synthesizing NIPAM nanoparticles as templates.The hydrogel is formed through a two-step polymerization process,and we investigate the effects of polymerization time and NIPAM monomer concentration on its temperature sensitivity,swelling ratio,self-repairability,and methylene blue encapsulation and release.Our results demonstrate that the hydrogel possesses a nano-porous structure with a lower critical solution temperature(LCST)of 32℃.It exhibits controllable swelling behavior,achieves self-healing functionality,and attains a methylene blue encapsulation rate of 53%with a release rate of 20%.These findings suggest its potential application in drug storage and transport involving small molecules.

关 键 词：水凝胶 温敏性 自修复性 包载与释放 

分 类 号：TQ311[化学工程—高聚物工业]