铁死亡在腹主动脉瘤发生机制中的研究进展  

Research progress on the role of ferroptosis in the pathogenesis of abdominal aortic aneurysm

作　　者：刘卓 慈红波[2] Liu Zhuo;Ci Hongbo(Graduate School of Xinjiang Medical University,Urumqi830000,China;Department of Vascular Surgery,Peoples Hospitalf Xinjiang UygurAutonomous Region,Urumqi 830001,China)

机构地区：[1]新疆医科大学研究生院,乌鲁木齐830000 [2]新疆维吾尔自治区人民医院血管外科,乌鲁木齐830001

出　　处：《中华胸心血管外科杂志》2025年第1期59-62,共4页Chinese Journal of Thoracic and Cardiovascular Surgery

基　　金：国家自然科学基金(82060096)。

摘　　要：腹主动脉瘤(AAA)是一种以腹主动脉局部扩张为特征的严重疾病,全球发病率呈上升趋势,且一旦瘤体破裂,病死率极高。AAA的发病机制复杂,目前非手术治疗疗效有限,亟须探索新的治疗靶点。近年来通过测序分析AAA组织中的差异基因表达,发现铁死亡相关基因在AAA中显著上调,且主要发生在血管平滑肌细胞(VSMC)中。铁死亡通过促进VSMC的表型转换和细胞死亡、诱导血管钙化、破坏细胞内氧化应激平衡、增强炎症反应的方式,加速AAA的进展。体外实验证明使用铁死亡抑制剂或过表达谷胱甘肽过氧化酶4(GPX4)可有效减轻小鼠AAA。本综述总结了铁死亡在AAA进展中的作用机制及其潜在的治疗靶点,旨在为AAA的防治提供新的思路。Abdominal aortic aneurysm(AAA)is a severe disease characterized by the localized dilation of the abdominal aorta,with an increasing global incidence and a high mortality rate once the aneurysm ruptures.The pathogenesis of AAA is complex,and current non-surgical treatments have limited efficacy,necessitating the exploration of new therapeutic targets.Ferroptosis is a form of programmed cell death that relies on iron and is non-apoptotic,primarily characterized by the uncontrolled peroxidation of lipids in the cell membrane.Studies have found that ferroptosis is significantly upregulated in AAA through differential gene expression analysis of AAA tissues,predominantly occurring in vascular smooth muscle cells(VSMCs).Ferroptosis accelerates the progression of AAA by promoting phenotypic switching and cell death of VSMCs and inducing vascular calcification.Additionally,ferroptosis exacerbates AAA by increasing reactive oxygen species production,altering the intracellular oxidative stress balance,and inducing inflammatory responses.Inhibiting ferroptosis-related pathways,such as by overexpressing glutathione peroxidase 4(GPX4)or using ferroptosis inhibitors,has been shown to effectively slow the progression of AAA in mice.This review summarizes the mechanisms by which ferroptosis contributes to AAA progression and its potential therapeutic targets,aiming to provide new insights for the prevention and treatment of AAA.

关 键 词：腹主动脉瘤 谷胱甘肽过氧化酶 差异基因表达 表型转换 血管钙化 AAA 铁死亡 炎症反应 

分 类 号：R543.16[医药卫生—心血管疾病]