Eclipse计划系统不同自动正常组织优化结构权重对腹部肿瘤调强放射治疗计划影响的研究  

Study on the effect of differently automatic normal tissue objective weights of Eclipse planning system on intensity modulated radiation therapy for abdominal tumor

作　　者：董伟洁 王春强 王林妮 韩爽 张野 李弈昕 Dong Weijie;Wang Chunqiang;Wang Linni;Han Shuang;Zhang Ye;Li Yixin(Department of Radiotherapy,The Second People’s Hospital of Huludao,Huludao 125000,China)

机构地区：[1]葫芦岛市第二人民医院放疗科,葫芦岛125000

出　　处：《中国医学装备》2025年第2期9-14,共6页China Medical Equipment

摘　　要：目的:对比研究Eclipse计划系统中不同自动正常组织优化结构(NTO)的权重(WNTO)对腹部肿瘤固定野调强放射治疗(IMRT)计划的影响。方法:选取2022年9月至2024年1月期间在葫芦岛市第二人民医院接受放射治疗的20例直肠癌患者和20例宫颈癌患者,每例患者分别制定WNTO 20、40、60、80和100的5组不同计划,其中WNTO20的计划为对照组,其他4组分别为WNTO40组、WNTO60组、WNTO80组和WNTO100组,比较5组计划的剂量学及机器跳数差异。结果:直肠癌患者WNTO80和100组计划中,靶区适形指数(CI)分别为1.02±0.04和1.00±0.03,趋近于1,低于对照组,差异有统计学意义(t=15.986、18.422,P<0.05),均匀性指数(HI)分别为0.09±0.12和0.10±0.14,高于对照组,差异均有统计学意义(t=-1.371、-1.463,P<0.05);小肠52 Gy剂量体积(V_(max52))分别为(4.48±14.49)和(4.77±10.47)cm^(3),高于对照组,差异有统计学意义(t=-1.360、-2.005,P<0.05);右股骨头30 Gy剂量体积百分比(V_(30Gy))分别为(12.28±4.57)%和(10.96±4.17)%,低于对照组,差异有统计学意义(t=6.893、6.750,P<0.05),左股骨头V_(30Gy)分别为(11.57±4.41)%和(10.17±3.78)%,低于对照组,差异有统计学意义(t=6.782、5.963,P<0.05);WNTO100机器跳数为(1254±93)MU,高于对照组,差异有统计学意义(t=-3.741,P<0.05)。宫颈癌患者WNTO80和WNTO100组计划中靶区CI分别为1.03±0.32和1.02±0.03,趋近于1,低于对照组,差异有统计学意义(t=20.069、19.475,P<0.05);HI分别为0.07±0.05和0.08±0.01,高于对照组,差异有统计学意义(t=-12.445、-19.478,P<0.05);右股骨头V_(30Gy)分别为(16.11±4.71)%和(14.90±4.56)%,低于对照组,差异有统计学意义(t=7.875、8.020,P<0.05);左股骨头V_(30Gy)分别为(15.21±3.71)%和(13.93±3.77)%,低于对照组,差异有统计学意义(t=7.617、7.436,P<0.05);小肠V_(max52)分别为(0.82±1.10)和(4.47±8.81)cm^(3),高于对照组,差异均有统计学意义(t=-2.985、-2.388,P<0.05)。结论:腹部肿瘤放射治疗计划推荐WNTO�Objective:To compare the effects of different automatic normal tissue objective(NTO)weights(WNTO)of Eclipse planning system on intensity modulated radiation therapy(IMRT)of fixed field for abdominal tumor.Methods:Twenty patients with rectal cancer and twenty patients with cervical cancer who received radiotherapy in The Second People's Hospital of Huludao from September 2022 to January 2024 were selected.5 groups of different plans[WNTO20,40,60,80 and 100]were respectively formulated for each patient.Among of them,the WNTO20 plan was control group,and other 4 groups were respectively WNTO40 group,WNTO60 group,WNTO80 group and WNTO100 group.Then,the differences in dosimetry and monitor units(MU)among 5 groups of plans were compared.Results:In the WNTO 80 and 100 groups of patients with rectal cancer,the conformation index(CI)values of target regions of them were respectively 1.02±0.04 and 1.00±0.03,all of which approached to 1,and the CI values of two groups were lower than that of control group,and the differences were statistically significant(t=15.986,18.422,P<0.05).The homogeneity index(HI)of WNTO 80 and 100 groups were respectively 0.09±0.12 and 0.10±0.14,which were higher than that of control group,and the differences were statistically significant(t=-1.371,-1.463,P<0.05).The 52Gy dose volume(V_(max52))of small intestine of the two groups were respectively(4.48±14.49)and(4.77±10.47)cm^(3),which were higher than that of control group,and the differences were statistically significant(t=-1.360,-2.005,P<0.05).The 30 Gy dose volume percentage(V_(30 Gy))values of the right femoral heads of the two groups were respectively(12.28±4.57)%and(10.96±4.17)%,which were lower than that of control group,and the differences were statistically significant(t=6.893,6.75,P<0.05).The 30 Gy dose volume percentage(V_(30 Gy))values of the left femoral head of the two groups were respectively(11.57±4.41)%and(10.17±3.78)%,which were lower than that of control group,and the differences were statistically significant(t=6.782,

关 键 词：直肠癌 宫颈癌 固定野调强 Eclipse计划系统 自动正常组织优化结构(NTO) 

分 类 号：R811.1[医药卫生—放射医学]