布洛芬模拟移动床手性拆分的多目标优化  

Multi Objective Optimization of Chiral Separation of Ibuprofen in Simulated Moving Bed

作　　者：李志雄 Li Zhixiong(Wenzhou University College of Chemistry and Materials Engineering,Wenzhou 325000,China)

机构地区：[1]温州大学,浙江温州325000

出　　处：《广东化工》2025年第1期51-53,69,共4页Guangdong Chemical Industry

摘　　要：模拟移动床(SMB)在手性药物分离方面具有广阔的应用前景。本文分别以产量和纯度同时最大化、溶剂消耗最小化和纯度最大化为优化目标,对具有非朗格缪尔吸附特征的布洛芬进行SMB多目标优化。通过优化后的m值对优化结果进行分析。Simulated moving bed(SMB)has broad application prospects in chiral drug separation.This article aims at optimize the production and purity simultaneously,minimize solvent consumption and maximize the purity of ibuprofen with non-Langmuir adsorption characteristics through SMB multi-objective optimization.Analyze the optimization results through the optimized m value.

关 键 词：模拟移动床 手性药物 多目标优化 非朗格缪尔型吸附 布洛芬 

分 类 号：O652.63[理学—分析化学]