基于手性纳米材料的毛细管电色谱手性拆分体系的研究进展  

Research Progress on Capillary Electrochromatography Chiral Resolution Systems based on Chiral Nanomaterials

作　　者：王晨 严菲 黄朝瑜 邵方娴 Wang Chen;Yan Fei;Huang Chaoyu;Shao Fangxian(Jiangsu Institute for Food and Drug Control,Nanjing 210019,China)

机构地区：[1]江苏省食品药品监督检验研究院,江苏南京210019

出　　处：《广东化工》2025年第1期91-93,共3页Guangdong Chemical Industry

基　　金：江苏省药品监督管理局科研计划项目(202209)。

摘　　要：毛细管电色谱兼具高效液相色谱的高效、高选择性和毛细管电泳的低溶剂和样品消耗的特点,是实现手性药物对映体分离的强有力的工具。近年来,手性纳米材料被广泛应用于毛细管电色谱领域实现手性药物拆分。常见的手性纳米材料包括金纳米粒子、金属有机骨架、共价有机骨架、金属有机笼、共价有机笼和磁纳米材料等。本文对应用于毛细管电色谱手性拆分体系的手性纳米材料进行了综述,以期对未来的毛细管电色谱手性拆分体系的构建提供参考。Capillary electrochromatography combines the high efficiency and high selectivity of HPLC with the low solvent and sample consumption of capillary electrophoresis,making it a powerful tool for chiral drug enantiomer separation.In recent years,chiral nanomaterials have been widely used in the field of capillary electrochromatography to achieve chiral drug resolution.Chiral nanomaterials include gold nanoparticles,metal-organic frameworks,covalent organic frameworks,metal organic cages,porous organic cages,and magnetic nanomaterials.In this paper,the chiral nanomaterials applied to the chiral resolution system of capillary electrochromatography are reviewed,in order to provide a reference for the construction of chiral resolution systems for capillary electrochromatography in the future.

关 键 词：毛细管电色谱 手性拆分 金纳米粒子 金属有机骨架 共价有机骨架 金属有机笼 多孔有机笼 磁纳米材料 

分 类 号：O657[理学—分析化学]