上转换发光材料的荧光增强策略及生物应用研究进展  

Progress in Fluorescence Enhancement Strategies and Biological Application of Upconversion Luminescent Materials

作　　者：尹玉 陈杰 刘蓉 王超 Yin Yu;Chen Jie;Liu Rong;Wang Chao(School of Chemistry and Pharmaceutical Engineering,Jilin Institute of Chemical Technology,Jilin 132022,China;Center of Characterization and Analysis,Jilin Institute of Chemical Technology,Jilin 132022,China)

机构地区：[1]吉林化工学院化学与制药工程学院,吉林吉林132022 [2]吉林化工学院分析测试中心,吉林吉林132022

出　　处：《中国稀土学报》2025年第1期13-28,共16页Journal of the Chinese Society of Rare Earths

基　　金：吉林省自然科学基金项目(YDZJ202101ZYTS029);国家自然科学基金项目(51902125);吉林市杰出青年人才专项项目(20210103092)资助。

摘　　要：上转换纳米发光材料是一类可以将长波近红外激发光子(NIR)转换成短波可见(VIS)和紫外(UV)发射光子的新型无机荧光材料。相比于传统的量子点和有机染料等荧光材料,上转换材料具有自荧光背景干扰小、生物组织穿透能力强和成像灵敏度高等优异性能,在生物医学成像、肿瘤等疾病诊疗领域引起了广泛关注。然而,由于上转换纳米粒子的结构缺陷会导致荧光猝灭效应,其发光效率普遍较低,这无疑限制了其广泛的实际应用。基于此,本文从上转换发光材料的发光机制出发,总结了影响上转换发光的主要因素以及提高上转换发光效率的方法,分析了上转换发光材料在生物应用领域取得的进展及目前存在的问题,为高性能上转换发光材料在生物医学领域的实际应用提供了参考。Upconversion nanomaterials as a new kind of inorganic fluorescent materials can convert long wavelength near infrared excited photons(NIR) into short wavelength visible(VIS) and ultraviolet(UV) emission photons.Compared with traditional fluorescent materials, such as quantum dots and organic dyes, upconversion nanomaterials have excellent properties such as low interference of fluorescence background, strong biological tissue penetration ability and high imaging sensitivity, which has attracted extensive attention in biological imaging, tumor diagnosis and treatment and so on. However, the upconversion luminescence efficiency is generally low since a large number of structural defects will cause luminescence quenching, which greatly limits their wide application. Based on this, this paper summarizes the main factors that affect upconversion luminescence, and the methods of enhancing the upconversion luminescence intensity according to the luminescence mechanism of upconversion materials. The progress and current problems of upconversion luminescent materials in the field of biological applications are analyzed, so as to provide reference for the practical application of high-performance upconversion luminescent materials in the field of biomedicine.

关 键 词：上转换发光 发光效率 荧光猝灭 核壳结构 疾病诊疗 稀土 

分 类 号：O734[理学—晶体学]