基于结构MRI观察0~6岁健康儿童大脑发育  

Observation on brain development of 0-6 years healthy children based on structural MRI

作　　者：俞玮 杨凤 杨康 冯章志 杨明[1] YU Wei;YANG Feng;YANG Kang;FENG Zhangzhi;YANG Ming(Department of Radiology,Children's Hospital of Nanjing Medical University,Nanjing 210008,China;School of Pediatrics,Nanjing Medical University,Nanjing 211166,China;Department of Clinical Medicine Engineering,Children's Hospital of Nanjing Medical University,Nanjing 210008,China)

机构地区：[1]南京医科大学附属儿童医院放射科,江苏南京210008 [2]南京医科大学儿科学院,江苏南京211166 [3]南京医科大学附属儿童医院临床医学工程处,江苏南京210008

出　　处：《中国医学影像技术》2025年第2期234-238,共5页Chinese Journal of Medical Imaging Technology

基　　金：南京市科技计划项目(202002055)。

摘　　要：目的基于3D-结构MRI(sMRI)观察0~6岁健康儿童大脑发育。方法回顾性分析228名0~6岁健康儿童脑3D-sMRI T1WI,获得总脑容量(TBV)、白质体积(WMV)、总灰质体积(tGMV)、皮质灰质体积(GMV)及皮质深部灰质体积(sGMV)各参数的绝对体积值及除TBV外的标准化值,测量皮质表面积和皮质厚度;分析上述各参数在各年龄段的变化。结果0~5岁期间,TBV及WMV、tGMV、GMV、sGMV绝对体积均增长(P均<0.05),且增长速度逐渐减慢;5~6岁期间,上述各参数增长均不明显(P均>0.05)。0~1岁期间,标准化WMV和sGMV均减小;1~4岁期间,标准化WMV逐渐增长(P均<0.05),而标准化sGMV无明显变化(P均>0.05);4~6岁期间,标准化WMV和sGMV均无明显变化(P均>0.05)。0~1岁期间,标准化tGMV和GMV随年龄增大而增长;之后1~6岁期间,除标准化tGMV于3~4岁期间出现明显减小外(P<0.05),其余参数均较稳定(P均>0.05)。全脑皮质表面积在0~5岁期间明显增长(P均<0.05),以0~3岁期间增长最快;5~6岁增长不明显(P>0.05)。0~1岁期间,全脑皮质厚度迅速增长,并于约1.5岁时达峰值;之后,均呈波动式变化,但变化不明显(P均>0.05)。结论健康儿童0~6岁期间大脑发育模式具有一定特征性。Objective To observe brain development of 0-6 years healthy children based on 3D-structural MRI(sMRI).Methods Brain 3D-sMRI T1WI of 228 healthy children aged 0-6 years were retrospectively analyzed.The absolute volume of total brain volume(TBV),white matter volume(WMV),total gray matter volume(tGMV),cortical gray matter volume(GMV)and subcortical gray matter volume(sGMV),as well as standardized values of the above indexes except for TBV were obtained,and the cortical surface area and thickness were measured.The changes of above parameters in different ages were analyzed.Results During 0-5 years,TBV and the absolute volume of WMV,tGMV,GMV and sGMV increased(all P<0.05)with gradually slowed down speed,while during 5-6 years,no significant increase of the above parameters was noticed(all P>0.05).During 0-1 year,standardized WMV and sGMV decreased,then the former gradually increased during 1-4 years(all P<0.05),while the latter did not change significantly(all P>0.05),and no significant change of standardized WMV nor sGMV were found during 4-6 years(all P>0.05).During 0-1 year,both standardized tGMV and GMV increased,while during 1-6 years,except for significant decrease in standardized tGMV during 3-4 years(P<0.05),other parameters remained relatively stable(all P>0.05).Cerebral cortex surface area increased during 0-5 years(all P<0.05),especially during 0-3 years,which did not obviously enlarge during 5-6 years old(P>0.05).Cerebral cortex thickness increased rapidly during 0-1 year and reached peak at about 1.5 years,then presented slow fluctuations without significant changes(all P>0.05).Conclusion Brain development of 0-6 years healthy children had certain characteristics.

关 键 词：儿童 脑 磁共振成像 

分 类 号：R72[医药卫生—儿科] R445.2[医药卫生—临床医学]