自拟通淋化瘀排石汤配合输尿管软镜对肾下盏结石排石情况、肾绞痛发生率及血清KIM-1水平的影响  

Impacts of self-made Tonglin Huayu Paishi decoction combined with flexible ureteroscopy on the stone excretion,incidence of renal colic,and serum KIM-1 level in patients with lower calyceal calculus

作　　者：李双辉[1] 尹文利[1] 王芳[1] 魏峰[1] 刘洪弟[1] Li Shuanghui;Yin Wenli;Wang Fang;Wei Feng;Liu Hongdi(Department of Urology,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Cangzhou 061000,China)

机构地区：[1]河北省沧州中西医结合医院泌尿外一科,沧州061000

出　　处：《国际泌尿系统杂志》2025年第1期14-18,共5页International Journal of Urology and Nephrology

基　　金：河北省中医药管理局2020年度中医药类科研计划课题(2020490)。

摘　　要：目的探讨自拟通淋化瘀排石汤配合输尿管软镜对肾下盏结石患者的排石情况、肾绞痛发生率及血清肾损伤分子-1(KIM-1)水平的影响。方法选取2020年1月至2021年9月在本院收治的160例肾下盏结石患者作为研究对象,按照随机数字表法将患者分为对照组和研究组,每组各80例。对照组给予输尿管软镜碎石术配合体位排石治疗,研究组给予输尿管软镜碎石术后配合化瘀通淋排石汤和体位排石法治疗。比较两组患者的排石情况、肾绞痛发生率及血清KIM-1水平。结果研究组患者不同时间点的结石排净率高于对照组,差异均有统计学意义(均P<0.05)。术后30 d,研究组患者的结石最大径低于对照组,差异有统计学意义(t=6.239,P<0.05)。研究组患者的术后血尿消失时间早于对照组,而肾绞痛发生次数少于对照组,差异均有统计学意义(均P<0.001)。术后10、30 d,研究组患者血清中性粒细胞明胶酶相关脂质蛋白(NGAL)、KIM-1水平均低于对照组,差异均有统计学意义(均P<0.05)。研究组的并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论采用自拟通淋化瘀排石汤配合输尿管软镜对肾下盏结石患者进行治疗,能够提高结石排净率,降低肾绞痛发生率,并且减少肾脏损伤。Objective To explore the impacts of self-made Tonglin Huayu Paishi decoction combined with flexible ureteroscopy on the stone excretion,incidence of renal colic,and serum level of kidney injury molecule-1(KIM-1)in patients with lower calyceal calculus.Methods A total of 160 patients with subcalyceal calculus admitted to our hospital from January 2020 to September 2021 were selected as the study objects,and the patients were divided into control group and study group according to random number table method,with 80 cases in each group.The control group was given flexible ureteroscopic lithotripsy combined with body position lithotripsy,and the study group was given flexible ureteroscopic lithotripsy combined with Tonglin Huayu Paishi decoction and body position lithotripsy.The stone excretion status,incidence of renal colic,and serum KIM-1 level of the two groups were compared.Results The stone removal rate of the study group was higher than that of the control group at different time points,and the difference was statistically significant(all P<0.05).The maximum stone diameter of the study group was lower than that of the control group at 30 days after surgery[(0.33±0.10)cm vs.(0.45±0.14)cm],and the difference was statistically significant(t=6.239,P<0.05).The disappearance time of hemuria in the study group was earlier than that in the control group[(7.15±2.44)days vs.(9.34±2.93)days],and the frequency of renal colic was less than that in the control group[(1.61±0.49)times/d vs.(2.29±0.76)times/d],with statistical significance(all P<0.001).At 10 and 30 days after surgery,serum neutrophil gelatinase-associated lipocalin(NGAL)and KIM-1 levels in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The complication rate of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusions The use of self-made Tonglin Huayu Paishi decoction combined with flexible ureteroscopic treatment

关 键 词：肾结石 输尿管镜检查 自拟通淋化瘀排石汤 肾绞痛 肾损伤分子-1 

分 类 号：R69[医药卫生—泌尿科学]