重视浆细胞病相关肾病的早诊早治  

Emphasis the early diagnosis and treatment of plasma cell disease-related kidney disease

作　　者：周慧星[1] 陈文明[1] 高文[1] Zhou Huixing;Chen Wenming;Gao Wen(Beijing Chao-Yang Hospital,Capital Medical University,Beijing Multiple Myeloma Research Center,Beijing 100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院,北京多发性骨髓瘤临床医疗中心,北京100020

出　　处：《中华医学杂志》2025年第4期257-260,共4页National Medical Journal of China

摘　　要：浆细胞病是一类涵盖从良性到恶性的复杂疾病,其所产生的单克隆免疫球蛋白,可导致多种肾脏疾病,表现为不同程度的肾功能不全,重者甚至需要透析或肾移植。治疗后肾脏功能改善滞后,部分患者获得血液学完全缓解后肾功能仍可进行性恶化。临床医师需提高对浆细胞病相关肾病的警惕和重视,早诊早治,这对逆转肾功能以及改善患者长期生存均有重要意义。Plasma cell disorders represent a spectrum of complex diseases,ranging from benign conditions to malignancies.The monoclonal immunoglobulins produced in these disorders can result in various renal pathologies,which may present as differing degrees of renal insufficiency.In severe instances,patients may necessitate dialysis or kidney transplantation.The recovery of kidney damage is relatively delayed after treatment.Some patients achieved hematological complete response,but kidney impairment may progressively worsen.Clinicians need to be more vigilant and pay more attention to PCD related kidney impairment.Early diagnosis and treatment are of great significance for reversing renal dysfunction and improving survival.

关 键 词：浆细胞病相关肾病 管型肾病 

分 类 号：R692[医药卫生—泌尿科学]